We are looking to hire a Structural Biologist to join us in our mission to discover and develop drugs that improve human health through the use of breakthrough computational methods. We are seeking outstanding individuals to join our drug discovery group and contribute to our rapidly expanding portfolio of drug discovery programs and collaborations.
Our drug discovery and early clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. The group is supported by more than 100 software developers and engineers as well as a large-scale computer infrastructure to apply our proprietary physics-based drug design and optimization platform. Ten of the programs we’ve worked on have progressed into preclinical development with four currently in clinical trials and one approved by the FDA.
Who will love this job:
- Someone with a passion for elucidating 3D structures of proteins and protein complexes, and with a vision of applying structure-based computational biophysics to drug discovery.
- Someone with deep knowledge of Structural Biology (protein crystallography and/or cryo-EM) who is excited to work with world class computational scientists.
What you will do:
- Work in a state-of-the-art Structural Biology team.
- Solve structures of macromolecules and protein complexes by X-ray crystallography and/or cryo-EM (working with internal resources and with external partners).
- Collaboratively work with biologists, biochemists, and computational scientists to assess, discuss, and present the value and impact of protein structures for drug discovery projects (for both small molecules and biologics).
What you should have:
- Demonstrated extensive knowledge of X-ray crystallography and/or cryo-EM;
- PhD in Structural Biology and 3 to 5 years of postdoctoral experience;
- Track record of success in Structural Biology with experience in drug discovery in a pharmaceutical setting (preferable but not required);
- Knowledge of molecular biology and protein biochemistry relevant for structural biology applications (DNA constructs design, protein expression systems, protein purification methods);