Scribe Therapeutics is seeking a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. The current role is for an In vivo Disease Biologist to join our Discovery team and advance our platform. The candidate should have a passion for working collaboratively with biologists and bioengineers to enable building the necessary tools for meeting the new frontier of CRISPR-based therapeutics. The ideal candidate should have expertise with in vivo study planning, common procedures in rodents, animal husbandry, and IACUC management. 

About Scribe:

Scribe uses holistic molecular engineering to design, evolve, build and apply exclusive CRISPR technologies with enhanced therapeutic attributes for in vivo use. The company’s first technology, X-Editing (XE) molecules, are highly engineered CRISPR enzymes that provide combined aspects of greater efficacy, specificity and deliverability than currently available CRISPR genome editing technology. While Scribe’s engineering core continues to evolve and expand, the company is simultaneously addressing diseases of significant unmet need— neurodegenerative disorders. 

Key Responsibilities:

  • Work with cross-functional disease biology teams to design and end-to-end execute in vivo study plans to support and inform early stage preclinical development.
  • Own, maintain, and scale up vivarium needs and processes. 
  • Develop, validate, and execute assays for in vivo readouts
  • Efficiently communicate results to team members verbally and in writing.
  • Effectively collaborate with members within a fully integrated team to facilitate execution on projects within established timelines.
  • Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science.

 

Required Skills and Background:

  • At least 1-2 years of experience working in an academic or industry lab, with a proven track record of hands-on experience in developing and executing in vivo study plans
  • PhD in Bioengineering, Biology, or equivalent.
  • High level of proficiency in different routes of administration in rodents, including systemic, ocular, and intracerebral injections.
  • High level of proficiency in tissue harvest, processing, and analysis via immunohistochemistry and common molecular biology techniques.
  • Experience with rodent husbandry, breeding, and vivarium maintenance.
  • Ability to rapidly learn, develop, optimize, validate, and execute novel assays. 
  • A strong work ethic, a steadfast commitment to discovery research and a documented ability to initiate, drive and complete research projects, as evidenced by a strong publication record.
    • Excellent interpersonal skills and ability to work efficiently and productively in a dynamic, scientifically rigorous, and fast-paced environment.
    • Strong organizational and documentation skills, effective verbal and written communication skills, and critical problem-solving and analytical skills
  • Ability to work both independently and collaboratively in a fast-paced, interdisciplinary research team.

 

Preferred Skills and Background:

  • Knowledge of preclinical development workflows.
  • Familiarity with CRISPR technologies and therapeutic approaches
  • Experience establishing and scaling up a vivarium. 
  • Familiarity with IACUC related processes.
  • Project management of early-stage therapeutic research projects.

 

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.




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