Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.
We are seeking a creative, passionate and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. The current role is for a Senior Research Associate to join our Technology Platform Team to support our Next-Generation Sequencing Platform Team. The candidate would bring a fundamental understanding of molecular biology, nucleic-acid chemistry, and NGS to contribute to the development and application of novel molecular assays for detection of genome editing events. The candidate should have a passion for working collaboratively with biologists and bioengineers to enable building the necessary tools for meeting the new frontier of CRISPR-based therapeutics.
The candidate will have numerous opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a leadership role of increasing responsibilities and the ability to publish highly impactful work in peer reviewed journals. This role will require expertise in molecular biology, high throughput sequencing technologies, mammalian systems and synthetic biology.
Key Responsibilities:
- Work closely across teams to generate high throughput sequencing data sets for their projects.
- Design and execute hypothesis-driven and properly controlled studies, analyze data with rigorous statistics, and write up publication quality reports.
- Effectively collaborate with members within a fully integrated team to facilitate execution on projects within established timelines.
- Contribute to novel assay development across sequencing platforms to expand Scribe’s NGS technology platform.
- Effectively present updates, and communicate research plans and timelines to the senior leadership team.
- Ability to work both independently and collaboratively in a fast-paced, interdisciplinary research team.
Required Skills and Background:
- Degree in molecular biology, bioengineering, genetics, biochemistry or a related field
- 5+ years of experience working in an academic or industry lab, with a proven track record of hands-on experience developing and scaling NGS based assays including implementation on high-throughput automated platforms
- Proficient with molecular genetics wet-lab techniques, particularly PCR, qPCR, ddPCR, and NGS library preparation (Amplicon sequencing, RNA-Seq, epigenomic sequencing assays, long-read sequencing)
- Familiarity with assay development in molecular biology and NGS, including both library preparation/sequencing and data analysis
- Hands-on experience operating and maintaining Illumina, PacBio, and/or Oxford Nanopore sequencing platforms
- Collaborative experience working with Computational Biologists, Biostatisticians, and Data Scientists to define data analysis approaches
- Inquisitive nature and a willingness to continuously learn about new areas of science and biotechnology, regardless of prior background in these domains. Demonstrated quantitative and scientific thinker as evidenced by a strong publication record
- Exemplify our values of integrity, creativity, drive and pragmatism
- Excellent interpersonal and communication skills with a demonstrated ability to work effectively in a team environment
Preferred Skills and Background:
- Industry experience in NGS based assay development and implementation
- Familiarity with long-read sequencing approaches (PacBio, Nanopore)
- Familiarity with unix command line, sequence alignment tools, and basic bioinformatics tools such as fastqc
- Experience working collaboratively across teams with a diverse set of skills including cell biologists, molecular engineers, bioinformaticians and computational biologists
- Experience with CRISPR-Cas gene editing systems and delivery technologies
- Experience mentoring junior scientists
Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Visit us at www.scribetx.com.
We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, disability, age, or veteran status.
At the time of posting, the base pay wage range for this role is $90,000-115,000 per year. The offered pay range will depend on internal equity and the candidate’s relevant skills, experience, qualifications, training, and market data. Additional incentives are provided as part of the complete package in addition to comprehensive medical and other benefits.
