Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.

We are seeking a highly creative, passionate, and motivated individual to join us in our quest to bring the next generation of CRISPR-based therapeutics into the IND enabling framework. The current role is for an In-Vivo Scientist. The candidate will be responsible for providing in-vivo pharmacology support of the Company’s product portfolio and pipeline from early-stage development through IND application and through clinical trial development. This role will require hands on in-vivo work as well as interaction with CROs for outsourcing research and potentially IND enabling in-vivo studies.

Key Responsibilities:

  • Lead the in vivo pharmacology aspect of multiple projects within discovery and development, provide in vivo physiology and pharmacology expertise.
  • Propose, plan, coordinate and supervise study execution at external CROs.
  • Develop and implement new animal models to support multiple gene editing targets.
  • Plan and conduct in vivo pharmacology studies: formulation and administration of gene editing therapeutics.
  • Analyze data from in vivo pharmacology and efficacy studies and perform statistical analysis.
  • Communication of experimental plans and data to multiple cross-functional scientific teams.
  • Contribute to preparation of study reports, regulatory filings, and project presentations.
  • Maintain excellent written documentation of completed experiments (e.g. electronic lab notebook and study reports).
  • Grow into mentoring early-career scientists on the team.

Required Skills and Background:

  • PhD degree in biology, biomedical engineering, or related field with 1-2 years of post-graduation experience in industry (preferred) or academia performing in-vivo experiments.
  • Experience planning and executing in-vivo studies, data analysis and interpretation.
  • Previous experience with CRISPR based gene editing is a plus.
  • Extensive experience working with small laboratory animals and well-established hands-on experience with in vivo dosing, bleeding, and handling techniques.
  • Attention to detail, critical analysis of data and troubleshooting abilities.
  • Good writing and communication skills; ability to understand and communicate scientific information.
  • Highly collaborative working style, and ability to adapt in a fast-paced environment.
  • Ability to work with minimal direction to meet objectives and timelines, adapting to changes and priorities to fulfill our mission.

Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to join our team of engineers and carve the future of therapeutics, then we are excited to hear from you! Visit us at  

We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, disability, age, or veteran status.

At the time of posting, the base pay wage range for this role is $110,000-130,000 per year.  The offered pay range will depend on internal equity and the candidate’s relevant skills, experience, qualifications, training, and market data.  Additional incentives are provided as part of the complete package in addition to comprehensive medical and other benefits.

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