Our mission is to engineer best-in-class CRISPR therapies that will permanently treat the underlying cause of disease in vivo. Scribe uses holistic molecular engineering to design, evolve, build and apply exclusive CRISPR technologies with enhanced therapeutic attributes. The company’s first technology, X-Editing (XE) molecules, are highly engineered CRISPR enzymes that provide combined aspects of greater efficacy, specificity and deliverability than currently available CRISPR genome editing technology. As Scribe’s engineering core continues to evolve and expand, the company will utilize XE and additional technologies to address diseases of significant unmet need, starting with a pipeline of therapeutics for neurodegenerative disorders. Scribe has already announced a research collaboration with Biogen Inc. to develop and commercialize CRISPR-based therapies that address the underlying genetic causes of Amyotrophic Lateral Sclerosis (ALS).

 

Scribe Therapeutics is seeking a highly creative, passionate, and motivated individual to join us as a Scientist on the platform engineering team designing and building new systems to deliver CRISPR in vivo. This role will require an expertise in molecular biology, mammalian systems & synthetic biology, and the creativity to synthesize and design novel parts and expression cassettes. This role will lead a small team project and has ample opportunities for professional and personal growth in a rapidly advancing biotechnology company. 

 

Key Responsibilities:

  • Work closely with a core engineering team to creatively design, rapidly build, and efficiently screen mammalian expression vectors for the controllable delivery of genome editing tools to target human tissues.
  • Design and execute hypothesis-driven and properly controlled studies, analyze data with rigorous statistics, and write up publication quality reports. 
  • Assume project responsibilities and effectively present updates, and communicate research plans and timelines to the senior leadership team internally and partners externally.
  • Effectively collaborate with members within a fully integrated team to facilitate execution on projects within established timelines.
  • Seamlessly interface and coordinate with other teams at Scribe to accomplish common goals.
  • Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science.

 

Required Skills and Background:

  • A PhD in Bioengineering, Cell or Molecular Biology, Synthetic Biology, Neuroscience or related discipline. 1+ years experience in a post-doctorate or in the pharmaceutical industry is a plus.
  • Experience with CRISPR-Cas gene editing systems and delivery technology desired.
  • Advanced expertise in the latest molecular and cellular biology techniques.
  • Expertise in use of mammalian cell reporter systems, screening in human cells, and readout by FACS and NGS analysis. 
  • Expertise in molecular biology, RNA and protein analysis (e.g. qPCR, RT-qPCR, Western, etc.) 
  • Demonstrated scientific productivity and drive as evidenced by a strong publication record.
  • Ability to work collaboratively in a fast-paced, interdisciplinary research team.
  • Excellent prioritization and organization skills.

 

Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Please contact us and include your CV or résumé. 

 

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