Programmable DNA, the software of Life, is finally here! Twist Bioscience is developing a disruptive Synthetic DNA technology that will change the world, enabling widespread health and sustainability. Synthetic biologists will use our products to engineer how organisms produce cures to diseases, make everyday chemicals by using the atmosphere as the carbon source, enable plants to make their own fertilizers, and to create in-vivo diagnostics that alert us when we are sick, and many more applications.

We are seeking an outstanding, innovative, and creative Scientist to join our antibody discovery effort. This scientist will have a unique opportunity to build the internal pipeline within the Pharma group and lead target discovery efforts utilizing molecular pharmacology and in vivo assays.

What You’ll Be Doing

  • Evaluate targets for the Twist Biopharma internal pipeline with the goal of bringing therapeutics from the early research stage to IND filing.
  • Develop clinically relevant in vitro cell based assays for receptor signaling
  • Assess receptor/ligand interactions, especially for large molecule biologics against hard-to-work with receptors
  • Develop strategies for robust membrane protein preparations
  • Evaluate and support the implementation of new technologies
  • Manage collaborations within industry and academia
  • Manage projects for CROs
  • Publish in high impact journals and present at scientific conferences
  • Lead projects internally and externally

What You’ll Bring to the Team

  • Expertise in understanding and assessing biologics drug discovery
  • Experience preparing proteins in cell lines, membrane preparations, detergents, viral-like particles, nanodiscs, etc.
  • Proficiency in molecular pharmacology
  • Strong background in cell culture, flow cytometry and in vitro cell based function assays
  • Your educational background includes a PhD in Pharmacology, Cancer Biology, Immunology, Cell Biology, biochemistry, or related discipline
  • Motivation to learn new scientific techniques and to work in a team environment is necessary
  • Ability to think outside the box is key
  • Your educational background includes a PhD in immunology, cell biology, biochemistry, or related discipline with outstanding publication record

 

Preferred Qualifications

  • Experience working with G protein-coupled receptors and antibodies
  • Background in microscopy and flow cytometry
  • Experience with molecular modelling and structural biology
  • Experience with primary cells, organoids and mice
  • Background in high throughput screening
  • Strong desire to work in a dynamic start-up environment is essential
  • Strong organization skills and proficiency in computer skills including various databases
  • Excellent oral/written communication and interpersonal skills a must
  • Proficiency with Microsoft Word, Excel, and PowerPoint

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is below. In addition to base salary, this role is eligible for bonus, equity, and a generous benefits package. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations.
San Francisco Bay Area Pay Range
$126,749—$151,248 USD

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