About Senda:

Senda Biosciences, Inc. is committed to bringing life-changing treatments to patients by harnessing nature’s code to program human cells—both from within and from outside—for targeted, potent, and tunable medicines. Senda’s proprietary platform includes an mRNA engine and the first-ever atlas of nature-derived programmable systems at the molecular level and across all kingdoms of life—accessing the entire code provided by nature required to program cells. With this platform, Senda is developing a new class of SendRNA™ medicines for infectious, genetic, metabolic, and autoimmune diseases, as well as oncology and powering new frontiers for mRNA therapeutics and vaccines and gene-editing and protein-based therapies. Headquartered in Cambridge, Massachusetts, Senda was founded by Flagship Pioneering. For more information, visit sendabiosciences.com or follow us on Twitter and LinkedIn.

The Position:

As a critical member of Senda Biosciences’ research team, the Sr./Principal Research Associate, Discovery will assist in the development and execution of strategies to enhance Senda’s SendRNA programmable medicines, with a particular focus on advancement and execution of high-dimensional measurements, bioanalytical method development and screening. The ideal candidate will have a strong foundational knowledge of chemical separation techniques, experience in LC/MS analysis and high-resolution mass spectrometry (HRMS). Working as part of a cross-functional team comprising, biologists, computational biologists, and analytical and formulations scientists, the candidate will contribute to the development of foundational data guiding the design of SendRNA programmable medicines.

Responsibilities:

  • Process samples from varied sources for analytical analysis
  • Oversee operation and maintenance of process critical analytical equipment
  • Design, develop, and implement analytical methods and workflows to meet the scientific need
  • Maintain a detailed, organized, and updated electronic laboratory notebook
  • Manage analytical supply inventory and reagent preparation
  • Contribute to the culture of scientific excellence at Senda

Required Experience:

  • BA/BS or MS (Preferred) in chemistry, biochemistry, chemical biology, or a related discipline with 3+ years of professional experience in a laboratory environment
  • Demonstrated application of solvent-based extraction methodologies
  • Experience with LC/MS method development and validation including the ability to independently troubleshoot, propose and implement solutions related to sample analysis
  • Experience, operational skills using high resolution mass spectrometry (HRMS) for small molecule research of metabolites and lipids
  • Familiarity with the physio-chemical properties of lipids and other biologically relevant metabolites
  • Strong organizational and record-keeping skills; and a high level of attention to detail
  • Comfort working with large sample numbers and various sample sources
  • Success in juggling multiple simultaneous efforts

Preferred Experience and Qualifications

  • with lipidomics workflows
  • with metabolite/degradant ID in DMPK setting
  • using advanced vendor and open-source software for data analysis of HRMS data (such as Compound Discoverer, SciexOS, PeakView, XCMS, MSDIAL etc.)
  • with data analysis of high-dimensional LC/HRMS data
  • with non-MS based detection (ELSD, CAD, etc.) and alternative separation methodologies (GC, SFC, etc.)
  • with laboratory automation
  • working in the pharmaceutical / biotechnology space

Senda Biosciences is an Equal Opportunity Employer. Senda does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

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