Summary

Reporting to the Head of Platform Biology, the Vice President of Delivery Sciences will be a key member of the R&D leadership team responsible for leading a cross-functional team of scientists developing and optimizing our innovative programable medicines. The ideal candidate will be a proven leader in nanoparticle delivery space from discovery to clinical development. While being responsible for the strategy, direction, and execution of Sendas nanoparticle delivery strategies this person will also provide strategic input on our short-term and long-term scientific strategy to the executive leadership team. This is a unique opportunity to be a major contributor to the success of a well-positioned, pre-IPO growth stage biotechnology company.

Responsibilities:

  • Manage and develop a rapidly growing team of scientists to successfully translate the platform from discovery to development
  • Oversee and lead the optimization of natural nanoparticle delivery systems to achieve superior efficacy, safety, potency, and durability
  • Establish, maintain, and be accountable for critical timelines pertaining to platform advancement
  • Work cross-functionally with research organization to prioritize, optimize, and nominate development candidates, design, and execute IND-enabling animal studies across disease indications, and establish scalable manufacturing process with analytical characterization
  • Interpret complex biological in vitro and in vivo data
  • Propose and drive new therapeutic demonstrations of the platform
  • Stay up to date in the field of delivery, identify possible collaborations, and present key information to both internal and external stakeholders
  • Manage both internal and external resources, including but not limited to CRO’s, collaborations, and partners
  • Generate new intellectual property and execute against existing intellectual property portfolio

Required Skills/Experience:

  • Broad leadership experience in nanoparticle-based delivery including natural and synthetic nanoparticles
  • Prior experience with high-throughput formulation screening in vivo and in vitro
  • Expertise in nucleic-acids therapeutics and delivery
  • Experience with protein/peptide delivery desirable
  • Experience with oral delivery of protein and nucleic acid-based therapeutics
  • Experience with delivery platforms for novel drug modalities including understanding in formulation and characterization
  • Skilled in the discovery, optimization, and use of cell-based assays for mechanistic studies
  • Analytical assay development
  • Ability to solve complex problems in a fast-paced environment
  • Ability to work cross-functionally in a matrixed environment
  • PhD. in an appropriate biological, chemical, or engineering field with a minimum 8+ years of relevant industry experience
  • Excellent verbal and written communication skills
  • Strong people management skills with demonstrated ability to manage high performing interdisciplinary teams, mentor and coach scientists and promote career development

About Senda Biosciences

Senda Biosciences, Inc. is uniquely positioned to transform human health by harnessing millions of years of evolution to program targeted, potent and tunable medicines. Nature has provided the codes to program human cells – both from within (mRNA) and from outside – from what surrounds them. The trillions of non-human cells in the human ecosystem have evolved natural nanoparticles that precisely shuttle biomolecules into human cells, providing the missing pieces to fully unlock programmable medicines. Senda’s proprietary platform includes the first-ever atlas of nature-derived programmable systems at the molecular level and across all kingdoms of life – accessing the entire code provided by nature required to program cells.  With this platform, Senda is developing a new class of SendRNA™ medicines.  The unique properties of these medicines create new frontiers for mRNA therapeutics and vaccines for infectious, genetic, autoimmune, and metabolic diseases and oncology indications – with further potential to transform the gene editing and protein-based therapy landscapes as well.  Based in Cambridge, MA, Senda was founded by Flagship Pioneering. For more information, visit sendabiosciences.com or follow us on Twitter and LinkedIn.

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