Company Overview:

Senda Biosciences, Inc. is pioneering a new field of medicine called Intersystems Biology.  People are a system of systems—both human and non-human. The constant molecular exchange between the hundreds of trillions of human and non-human cells within us, such as plant and bacterial cells, defines life as profoundly as our genetics. Senda is systematically harnessing these powerful molecular exchanges—the product of millennia of co-evolution—to create new classes of programmable medicines. Built on insights from Intersystems Biology, Senda’s X-VIA™ drug development platform is the first-ever atlas of interspecies exchange mechanisms, enabling next-generation nucleic acid, genetic and protein-based therapies. These therapies will enable new frontiers for medicines, such as programmable tissue targeting beyond the liver for nucleic acid, cell, and gene therapies; tunable immunomodulation for both in vivo immune system stimulation and suppression; repeatable dosing of therapeutic modalities that were previously impossible; and multiple routes of administration, including enabling oral routes for large biomolecules for the first time.

Senda was unveiled by Flagship Pioneering in October 2020, and the company entered into a strategic collaboration with Nestlé Health Science in 2021 focused on novel nutritional therapies for a wide range of metabolic conditions. Senda is based in Cambridge, MA. For more information, please visit sendabiosciences.com or follow us on Twitter or LinkedIn.

The Position:

We are seeking a Sr. Research Associate to join the Bacterial Derived Transfer (BDT) team at Senda Biosciences.  This individual will play a key role in the deployment of in vitro assays vital for advancement of the platform.  Working as part of a highly collaborative team, this candidate will be primarily responsible for maintaining mammalian cell lines and conducting a variety of cell-based assays.  In addition, this candidate will assist in bacterial strain engineering and be regularly involved in bacterial cloning workstreams.  This individual will be a key member of Senda’s dynamic, expanding, and collaborative team that combines significant experience in microbiome-based taget discovery, microbe-host interactions, drug deployment, and human health to unlock the potential of the company’s core technological platforms.  

Key Responsibilities:

  • Conduct mammalian cell culture
  • Design/optimize/perform in vitro cell-based assays
  • Conduct quantitative molecular biology assays  
  • Assist in bacterial cloning workstreams 
  • Assist in the production and characterization of microbial products 
  • Work with senior research staff to design, execute, and interpret experiments 

Required Skills/Experience: 

  • MS in a biology or related field (or BS with 2+ years of experience) 
  • Excellent aseptic technique
  • Proficient in mammalian cell culture (starting cells from cryo, seeding at precise cell densities, passaging, cryopreservation)
  • Experience working with a variety of mammalian cell lines
  • Experience with plate-based assays (e.g. ELISA, cytotoxicity, etc.)
  • Proficient in microbial cell culture   
  • Experience working with plasmids and cloning in bacteria 
  • Familiar with molecular biology techniques: PCR, gel electrophoresis, molecular cloning, and sanger sequencing 
  • Strong organizational and communication skills  

Desired Skills/Experience: 

  • Experience culturing and cloning in diverse microbial organisms 
  • Familiar with a subset of the following bacterial cloning techniques: lambda red recombineering, Gibson assembly, Type II2S restriction cloning, Golden Gate assembly, allelic exchange cloning
  • Track record of independent cloning workstreams in the lab 
  • Immunoblotting 

 

Senda Biosciences is an Equal Opportunity Employer. Senda does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.

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