Totus Medicines, an innovative therapeutic drug discovery biotech, is just emerging from stealth. With a $40M Series A, Totus is poised to revolutionize drug discovery. For the first time, Totus is enabling genome-scale drug discovery to allow the identification of precision medicines for hard-to-drug targets. At its core, Totus is a chemical biology company. Totus’ novel proprietary platform allows screening at a rate more than 100,000 times faster than competitive technologies. Totus has pioneered the development of selective medicines for patients with genetically defined cancers and plans for its first program to enter Phase I by end of 2022. Totus also plans to expand their platform to create therapeutics targeted at neurodegeneration, infectious diseases, and others. We are searching for talented, passionate, high-energy candidates to join our growing team.

About the Role:

We are seeking a Scientist to help drive our DNA-encoded library (DEL) development team

Responsibilities

  • Maintaining a high level of productivity in the laboratory setting.
  • Working with autonomy to design experiments, interpret data, and propose next steps.
  • Preparing DNA-encoded small molecules through DNA ligation and other molecular biology techniques.
  • Running DEL selections, NGS prep, and NGS
  • Coordinating with DEL chemistry group for hit resynthesis
  • Collaboratively supporting the advancement of compounds from initial identification in DEL selection data, hit resynthesis, and early hit expansion.
  • Working on novel, testable hypotheses to enable clear decision-making.
  • Contributing to scientific strategies and goals within a team setting.
  • Presenting data and reports on project status at individual and group meetings.

Qualifications:

  • Ph.D. or equivalent experience
  • Hands-on experience (2-10 years) across the entire workflow of DNA-encoded libraries production in industrial or academic setting
  • Knowledge of modern synthetic chemistry reactions applicable to DEL technology
  • Knowledge of industry safety standards in chemistry labs
  • Strong organizational and time-management skills
  • Excellent written and oral communication skills
  • Team player; comfortable and effective in a collaborative research environment
  • Experience mentoring junior level employees

What We Offer

  • A knowledgeable, high-achieving, experienced and fun team

  • A diverse work atmosphere

  • The chance to be part of a growing startup and the next success story

  • The opportunity to shape our company culture

  • Constant learning and dynamic challenges to help you grow and be the best version of yourself

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