Totus Medicines, an innovative therapeutic drug discovery biotech, is just emerging from stealth. With a $40M Series A, Totus is poised to revolutionize drug discovery. For the first time, Totus is enabling genome-scale drug discovery to allow the identification of precision medicines for hard-to-drug targets. At its core, Totus is a chemical biology company. Totus’ novel proprietary platform allows screening at a rate more than 100,000 times faster than competitive technologies. Totus has pioneered the development of selective medicines for patients with genetically defined cancers and plans for its first program to enter Phase I by end of 2022. Totus also plans to expand their platform to create therapeutics targeted at neurodegeneration, infectious diseases, and others. We are searching for talented, passionate, high-energy candidates to join our growing team.

The AD/Director of Medicinal Chemistry will be accountable for leading the strategy on a Totus small molecule drug discovery program. The successful candidate will collaborate with an interdisciplinary team of scientists to advance projects toward IND enabling studies. 

Key Responsibilities:

  • Lead medicinal chemistry strategy on a Totus drug discovery program
  • Support chemistry team build out and external chemistry strategy
  • Foster a highly collaborative interdisciplinary scientific environment
  • Develop internal talent through close mentorship, positive support while enabling and motivating talent to drive science and their professional growth

What You’ll Bring to the Team:

  • 8+ years of industry experience in medicinal chemistry
  • Track record of advancing small molecule drug discovery programs to IND enabling studies
  • Experience in the design and synthesis of covalent inhibitors is a plus
  • Experience in structure-based drug design is a plus
  • Ability to communicate effectively across scientific disciplines
  • Experience working with CROs in all aspects of medicinal chemistry
  • Strong record of effective mentorship and management of internal chemists

What We Offer

  • A knowledgeable, high-achieving, experienced and fun team

  • A diverse work atmosphere

  • The chance to be part of a growing startup and the next success story

  • The opportunity to shape our company culture

  • Constant learning and dynamic challenges to help you grow and be the best version of yourself

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