Totus Medicines, an innovative therapeutic drug discovery biotech, is just emerging from stealth. With a $40M Series A, Totus is poised to revolutionize drug discovery. For the first time, Totus is enabling genome-scale drug discovery to allow the identification of precision medicines for hard-to-drug targets. At its core, Totus is a chemical biology company. Totus’ novel proprietary platform allows screening at a rate more than 100,000 times faster than competitive technologies. Totus has pioneered the development of selective medicines for patients with genetically defined cancers and plans for its first program to enter Phase I by end of 2022. Totus also plans to expand their platform to create therapeutics targeted at neurodegeneration, infectious diseases, and others. We are searching for talented, passionate, high-energy candidates to join our growing team.

Totus is seeking an individual who can immediately contribute as a member of the Executive Committee and who has ideally worked as a member of a management team for a business which has seen a similar rapid evolution. Unlike many very small companies, culture plays a key role in the organization. The vision of the CEO is that “culture beats strategy,” meaning that a great team will overcome the challenges that are sure to present to an early-stage organization. This individual will embrace this philosophy, not only for themselves, but for the diversity and quality of the team that they will build at Totus.


  • Build and lead a multidisciplinary chemical biology team integrating high-throughput chemistry (parallel synthesis, DNA-encoded libraries), high-throughput screening (Tecan/Echo techniques), biophysics (Mass Spectrometry/Crystallography), early discovery biology (hit validation and prosecution to in vivo POC), and new chemical biology techniques (assay development, platform innovation).
  • Provide leadership and oversight to the Automation Engineering and High-Throughput Assays functions, including creating a vision, strategy and operating model for use of integrated automation solutions in cell therapy development.
  • Working cross-functionally with biology, chemistry, and other disciplines to develop and optimize established and novel methodologies to assays
  • Managing CROs and determining balance of internal and external resources

Key Qualifications:

  • A demonstrable track record of impact and innovation in the field
  • A proven track record of scientific and people leadership
  • 12+ years prior experience in biotech or pharma
  • Ph.D. in Biophysics, Biochemistry, Chemical Biology or related discipline
  • Expertise and understanding in the following: biochemical assay development, biophysical methods, cell-based screening, the effects of protein motion on ligand binding, small molecule HTS, protein production, binding affinity, and functional assays
  • Ability to lead, or contribute to, multi-disciplinary teams to advance programs toward the clinic
  • Strong track record of scientific accomplishments including in small molecule drug discovery and development, as indicated with patents and/ or publications
  • Demonstrable use of communication skills to create a collaborative environment and trust across departments and within the team through empowerment, promotion of people, and shared responsibilities
  • Ability to seamlessly tailor communication with a variety of audience both internally and externally
  • Participate in establishing strategic plans and objectives and ensuring operations effective achievement of objectives

What We Offer

  • A knowledgeable, high-achieving, experienced and fun team

  • A diverse work atmosphere

  • The chance to be part of a growing startup and the next success story

  • The opportunity to shape our company culture

  • Constant learning and dynamic challenges to help you grow and be the best version of yourself

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