Totus Medicines is an innovative therapeutic drug discovery biotech that has developed a platform focused on targeted covalent drugs. This novel proprietary platform allows screening at a rate more than 100,000 times faster than competitive technologies and has the potential to expand the spectrum of drug targets to be screened for any disease process.

We are seeking a candidate with leadership skills to lead the computational chemistry team. Reporting to the Chief Data Officer, you will bring expertise in cheminformatics, data science, molecular modeling, and library design. You will be part of a dynamic organization and therefore you should be comfortable in a “building-mode” biotech setting where you will shape the company’s scientific strategy, culture, and mission. If this role excites you, reach out to Totus Medicines today to learn more.

In this role you will: 

  • Hire, develop, mentor and lead a team focused on cheminformatics, molecular modeling and structure-based drug design
  • Co-develop a novel strategy for covalent drug discovery
  • Foster an environment of innovation and entrepreneurship to build, integrate and apply computational tools and workflows
  • Provide hands-on computational chemistry support for drug discovery projects
  • Guide innovation around small molecule computational design and optimization
  • Interact and form strategic partnerships with key stakeholders in the discovery platform, the chemical design and development groups
  • Collaborate closely with Data Engineering
  • Champion Totus’ culture of embracing scientific excellence, agility, integrity with a sense of urgency and collaboration

Requirements: 

  • Ph.D. with 8+ years of industry experience in computational chemistry, cheminformatics, chemical biology, ML, data science, and drug discovery 
  • Proven leadership experience in driving teams towards common scientific goals and leading scientific drug discovery-focused activities
  • Demonstrated ability to implement complex analysis in computational chemistry on drug discovery projects and the enablement of innovative data science platforms
  • Proven track record of success in drug discovery project activities
  • Experience in oncology drug discovery, proteomics and chemical biology is beneficial
  • Agility and eagerness to troubleshoot or adjust to scientific changes as necessary
  • Ability to communicate effectively with cross-functional teams and contribute to critical decision making 
  • Big picture thinking with an enthusiasm to drive computational methods forward to help develop novel therapies for patients

What We Offer

  • A knowledgeable, high-achieving, experienced and fun team

  • A diverse work atmosphere

  • The chance to be part of a growing startup and the next success story

  • The opportunity to shape our company culture

  • Constant learning and dynamic challenges to help you grow and be the best version of yourself

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