Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

Tango’s labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston.


Reporting to the VP Program Management, this person will play an instrumental role in organizing and advancing critical portfolio programs, facilitating timely and impactful decisions, and contributing to the development of overall program strategy at Tango Therapeutics. This is an opportunity for a versatile individual to become an integral member of our R&D teams, further establishing the program management function as a key value driver for Tango Therapeutics.  Together with program leaders (PL), this individual develops integrated drug discovery and development plans for the selection and progression of oncology clinical candidates into clinical development and registration. In this role you will ensure organizational alignment and oversee program execution at Tango and CROs, as well as foster team building and a collaborative environment.

Your Role:

  • Leads program management activities for one or more small molecule cancer therapeutics through development candidate selection to clinical Proof of Concept (POC) and into full development and registration
  • Supports the PL and the discovery program team in the development of the program strategy for selection of the development candidate (DC) and progression into clinical development by planning and tracking activities in lead optimization, pharmacology, toxicology and ADME studies, preclinical work for patient selection and indication expansion, drug supply and formulation development and clinical planning and operations
  • Guides the development team through clinical development by creating and executing on an integrated clinical plan for POC and registration. Develops and assesses different scenarios for accelerated approval based on clinical outcomes from the first in human studies of the single agent and its combination with other targeted therapies. Works with sub-teams in manufacturing, clinical operations, safety, translational biology, regulatory and commercial to ensure that functional activities are fully integrated into the clinical development plan and support indication expansion and regulatory approval
  • Achieves organizational alignment and seamless execution of the integrated drug discovery and development plans by working cross-functionally within Tango and with CROs
  • Defines critical path, at-risk activities, and inter-dependencies. Anticipates bottlenecks, clears barriers to progress program level scenario planning & risk management
  • Represents, as needed, the program team to discussions with leadership teams, scientific founders, and Directors
  • Tracks program progress against the plan, working with department heads to identify and resolve resource constraints consistent with corporate priorities
  • Supports active portfolio management (budget, resources, stage-gates) and decision-making and monitors progress of portfolio/program strategy, goals, and metrics
  • Establishes, together with the PL, program and individual goals that are aligned with corporate goals
  • Schedules, facilitates, and documents Program Team and ad-hoc program meetings; ensures uniformity between programs including agendas, meeting minutes and other program documentation
  • Identifies, tracks, and supports resolution efforts for all program-related issues. Relays positive and negative deviations from program plans to the program team and management
  • Facilitates resolution of conflicts between functional groups while maintaining objectivity
  • Ensures high-performing project teams by monitoring and assessing team effectiveness at both team and individual levels
  • Additional duties and responsibilities as required

What You Bring:

  • Bachelor's degree required
  • Minimum of 10 years of relevant biotech or pharmaceutical industry experience is required
  • Minimum of 3 years in a program management role required
  • Hands on experience in leading program management activities in early and/or full clinical development is required
  • Experience in at least one of the functions related to pharmaceutical development (e.g. Research, Regulatory Affairs, Clinical Dev/Operations, CMC) is required
  • Experience in oncology development is preferred
  • Must demonstrate good leadership and team building skills, ability to influence cross-functionally, work with different personalities and styles and maintain positive interpersonal relationships
  • Excellent written and verbal communication are essential, with the ability to clearly present and communicate complex program information in both formal and informal settings
  • Strong conflict resolution and problem-solving skills with an ability to handle complexity and ambiguity
  • Experience with Risk Management and Contingency Planning preferred
  • Experience setting and maintaining budgets preferred
  • Knowledge of project management tools and software (MS Project, etc.)
  • PMP certification a plus


We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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