Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts
Summary
We have an exciting opportunity to join our Immunology team as an Associate Scientist I/II. You will be an innovative, collaborative, and enthusiastic Associate Scientist and will help to build our Immunology and Immuno-Oncology programs. You will work primarily at the bench to help drive target identification, validation, and patient selection strategies.
Your Role:
You will culture and engineer human and murine primary and tumor cells using genetic tools
Be responsible for the assessment and analysis of cancer and immune cell function and phenotype using multicolor flow cytometry, ELISA, western blotting, gene expression analysis, and other cell-based assays
Perform immune cell functional and phenotypic assays including proliferation, differentiation, and exhaustion assays, and co-cultures with tumor cells
Prepare samples for sequencing, gene expression, and protein expression analysis
Mouse tissue harvesting and processing for down-stream applications
Assist with the training of lab personnel
Work collaboratively and independently within an engaged team environment
Additional duties and responsibilities as required
What You Bring:
BS or MS in cancer biology or immunology (or related) with 1-7 years’ experience in industry or related academic lab(s)
Experience with cancer biology and/or immuno-oncology preferred
Experience with tissue culture, cell-based, and molecular assays (e.g. western, Q-PCR, ELISA, CTG)
Experience performing flow cytometry and related data analysis
Experience with immune cell functional, phenotypic assays, and co-cultures with tumor cells preferred
Experience with mouse handling and tissue harvesting/processing a plus
Ability to analyze and present data
Excellent record-keeping skills
Strong written and oral communication skills
Independent, flexible, self-motivated
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.