Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. 

Whether it's the biological diversity of our gene editing systems or the people that help discover them, Metagenomi celebrates the diversity of life. This is achieved through a compassionate culture that acknowledges the dimensions of our diversity.  We know that when people feel a sense of inclusion and belonging in the workplace, they have a safe space to bring creativity and innovation to everything they do. We are intentional about building and maintaining a culture where people are valued and respected, there is equity in opportunities, and our respective opinions and differences matter.

 

We are hiring a Manager, Plasmid Process Development, to develop and lead Metagenomi’s plasmid production processes.  Reporting to the Director, Process Engineering, this position is responsible for tracking lots, drafting budgeting forecasts, managing plasmid/mRNA requests from other functional areas, and trending relevant data to propose optimizations to the process for improved purity, scaling up to enable GMP plasmid production in-house, further bolstering our mRNA capabilities.  The role is based in Emeryville, California. 

How you’ll contribute: 

  • Partner with technical operations to manufacture plasmid to support the mRNA-based gene editing systems, including bacterial transformation, colony selection, cell banking, fermentation, harvest, chromatography, TFF, linearization, polishing, and functional testing for mRNA production. 
  • Support RNA synthesis by in-vitro transcription and nucleic acid purification
  • Support nucleic acid characterization with UV absorbance, PCR, capillary/gel electrophoresis
  • Determine Critical Process Parameters(CPPs) and partner with Metagenomi’s  Analytical team to define Critical Quality Attributes (CQAs)
  • Support process optimization efforts,  improving robustness and quality of mRNA and plasmid
  • Draft experimental protocols, technical reports, Batch Records, SOPs, and material specifications
  • Support technology transfers and engineering runs
  • Contribute to root cause analyses for deviations and CAPAs
  • Provide general laboratory assistance, including lab equipment maintenance, ordering of lab supplies, preparation of reagents, and compliance with safety policies

Must haves:   Knowledge, Skills, Abilities:

  • Undergraduate degree, advanced degree preferred  in Molecular Biology or a closely related discipline 
  • At least 10 (B.S.), 6 (M.S.), 3 (Ph.D.) years of industry experience in Research or Process Development 
  • Experience with TFF, Akta Pure/Avant, and Chromatography systems for mRNA and plasmid
  • Nucleic acid characterization with UV absorbance, PCR, capillary/gel electrophoresis
  • Experience with LNPs and downstream activities 
  • Project Management and team leadership experience
  • Extremely organized and able to efficiently manage your time and workflow, including skillfully prioritizing long-term projects and day-to-day responsibilities.

California Pay Transparency Disclosure:

Under the Federal Labor Standards Act, this position is classified as exempt. Its anticipated base salary range will be $130,000 to $170,000. Depending on the position offered, you will also be eligible to receive equity, bonuses, and a full range of benefits. Please note that individual total compensation for this position will be determined at the Company’s sole discretion and may vary based on location, skill level, years and depth of relevant experience, and education. 

#LI-NG1

 

 

What makes Metagenomi a unique place to work?

  • We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating diseases.
  • We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more! 
  • We offer competitive compensation, including a market-benchmarked salary, annual target bonus potential, equity, comprehensive benefits plan, 401(k) with company matching, retirement safe harbor plan, and other perks.

At Metagenomi, we know that our people drive our success. We are an equal opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. 

Applicants/Employees have rights under various State and Federal Employment Laws, including without limitation:

Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.

 

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