We are seeking an independent, goal-oriented, and motivated individual for a Scientist position to evaluate novel genome editing systems for in vivo therapeutics as a member of our growing Pre-Clinical research team. Reporting to and collaborating with the project team leader, this position will play a crucial role in enabling next-generation gene editing therapeutics, including the characterization of the therapeutic target as well as the effects of gene editing in both cells and animal models. You will have the opportunity to make a lasting impact as you partner with the therapeutic project, guide RNA screening and chemistry, specificity, NGS, and animal models teams in order to advance projects toward the clinical phase. This role will be based in Emeryville, California


About the Role

The day-to-day responsibilities of this role will include:

  • Perform transfection of primary cells and cell lines to support lead identification and selection for pipeline programs
  • Perform molecular analysis of in vitro and in vivo editing outcomes using next-generation sequencing, quantitative PCR, and RNA sequencing
  • Analyze the effect of gene editing employing multiple biochemistry techniques (Western Blot, ELISA, activity assays)
  • Collaborate internally and with external partners on the optimization of non-viral and viral delivery approaches
  • Employ non-viral and viral delivery approaches to plan in vivo studies and perform various molecular analyses to support internal therapeutic programs (handling animals not required)
  • Independently trouble-shoot technical issues as needed
  • Analyze and interpret experimental data and present results at team, company-wide, and external scientific meetings
  • Contribute to the selection and design of therapeutic strategies
  • Provide mentorship and training to research associates as appropriate
  • Prepare accurate and timely data summaries and contribute to written reports, papers, and intellectual property

Desired Qualifications 

  • PhD or equivalent experience in biology, biochemistry, molecular biology, or a related discipline
  • Experience with DNA, RNA, and protein analytics
  • Track record of challenging oneself to enhance scientific skills and knowledge
  • Experience with aseptic cell culture techniques, including cell transfections
  • Experience with quantitative PCR or digital droplet PCR
  • Experience with biochemical analysis techniques (Western Blot, ELISA, Enzyme activity assays, Immunostaining)
  • Experience with NGS data generation and interpretation
  • Effective oral and written communication skills, particularly when collaborating with other teams with limited knowledge of your area of expertise
  • Organized and able to efficiently manage your time and workflow, including skillfully prioritizing both long-term projects and day-to-day responsibilities
  • Ability to work independently as well as in a results-oriented team
  • Able to quickly learn and adapt to new software tools (e.g. Benchling, Geneious, Prism, etc.)
  • Thrives in a fast-moving, results-oriented startup environment with urgent deadlines and rapidly-changing priorities and timelines
  • Self-motivated, passionate about your work, and eager to continuously learn
  • Flexible, cooperative, can-do attitude


Preferred additional qualifications:

  • Hands-on experience with genome editing technologies
  • Experience with mRNA and lipid nanoparticle technologies


The anticipated base salary range for this position will be $115,000 - $130,000 depending on the exact level of the role. As this role is open to candidates with a wide range of skills and experience, the exact salary will be dependent on the specific level of the position. We value transparency and will make every effort to provide you with a succinct explanation for how the final salary within this range is determined.


Please note, all candidates must be authorized to work in the United States.


About Metagenomi

Metagenomi is a gene editing company committed to developing potentially curative therapeutics by leveraging a proprietary toolbox of next-generation gene editing systems to accurately edit DNA where current technologies cannot. Our metagenomics-powered discovery platform and analytical expertise reveal novel cellular machinery sourced from otherwise unknown organisms. We adapt and forge these naturally evolved systems into powerful gene editing systems that are ultra-small, extremely efficient, highly specific and have a decreased risk of immune response. These systems fuel our pipeline of novel medicines and can be leveraged by partners. Our goal is to revolutionize gene editing for the benefit of patients around the world. For more information, please visit https://metagenomi.co/.


What makes Metagenomi a unique place to work?

  • We are passionate about developing technologies derived from microbial-rich ecosystems that have the power to enable therapeutic development and the potential to cure devastating disease.
  • We have cultivated an amazing culture that values teamwork, curiosity, scientific rigor, and fun. We have a strong commitment to work/life balance, host a weekly employee happy hour and events, provide catered lunches and endless snacks, and more! 
  • We offer competitive compensation including a market-benchmarked salary, annual target bonus, equity in an early-stage startup, and a comprehensive benefits plan, including 401(k) matching, a retirement safe harbor plan, and other perks.


At Metagenomi, we know that our people drive our success. We are an equal-opportunity employer and believe in and value diversity and inclusion. Metagenomi provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Metagenomi does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law. Please note, all candidates must be authorized to work in the United States.


Applicants/Employees have rights under various State and Federal Employment Laws, including

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Notice to agencies: Our in-house Talent Acquisition Team manages all employment opportunities at Metagenomi. Agencies and independent recruiters must be approved as a vendor by Metagenomi’s Talent Acquisition team. To protect the interests of all parties, Metagenomi will not accept unsolicited resumes, profiles, or biographies. Any unsolicited resumes sent to Metagenomi will be considered referrals and the property of Metagenomi.


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