About Maze Therapeutics

Maze is a clinical-stage biopharmaceutical company harnessing the power of human genetics to transform the lives of patients through the development of a pipeline of novel precision medicines for patients with genetically defined diseases. Maze is leveraging Compass™, a proprietary, end-to-end purpose built platform to advance a pipeline of precision medicines across four disease areas - renal, cardiac, neurological and metabolic diseases. Our flexible business model aims to translate our genetic insights into new therapies for patients as possible.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.  

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. 

Stand True – Our integrity is foundational; it guides us no matter the obstacle. 

Role Description:

We are seeking a VP of Clinical Development who will be responsible for the strategy, direction, and execution of the company’s clinical development plans. Reporting to the President and Head of R&D, this individual will be responsible for building and leading the clinical sciences organization as business needs evolve. The leader will oversee Clinical Sciences, be a critical connector between research, development, and business functions, and will be a key member R&D Leadership Team, which determines and oversees research and drug development at Maze, and the senior management team that plays an essential role in setting the overall strategic direction of the company.

Your Impact Includes:

  • Managing and maintaining strong, effective relationships with key external stakeholders and partners (i.e. KOLs and investigators, global vendors, consultants, patient advocacy groups, and other external clinical trial participants) to ensure that the primary goals of the clinical development programs are met
  • Responsible for representing the company to global regulatory and legislative agencies, addressing the scientific and medical/health aspects of the company's product portfolio
  • Managing medical strategy, questions, and internal and external relationships that are related to our clinical programs
  • Providing leadership and direction for all medical activities including medical monitoring
  • Drafting and reviewing medical aspects of core study and regulatory documents (i.e. protocols, investigator brochures, INDs, briefing documents, etc.)
  • Accountable for submission of essential documents to the TMF and Regulatory Department, as needed; Managing and coordinating clinical development deliverables, per vendor and CRO contracts, to ensure project deliverables are met on time and within budget
  • Accountable for all necessary templates and documentation (i.e., manuals, guides, communication plans) for clinical studies
  • Assisting with the generation, analysis, and presentation of clinical data, including manuscripts, abstracts, and oral presentations (including authoring documents and slide preparation as appropriate)
  • Communicating in a timely and effective manner with colleagues on the R&D leadership team, executive management, and others, including the board of directors, on clinical trial status and activities
  • Conduct investigator meetings and participate in site visits with clinical trial investigators when needed
  • Execute and deploy clinical development strategic plans, develop contingency plans, provide technical and strategic advice, and meet milestones and budgets
  • Strong partnership with heads of Research, Drug Discovery, and Preclinical Science
  • Conduct clinical trials using ethical guidelines relevant to the pharmaceutical industry, and ensure compliance with these external guidelines


  • M.D., M.D. / Ph.D., or equivalent degree with postgraduate training and clinical experience in Medicine, Pediatrics, Surgery or equivalent highly preferred
  • Minimum of 10 years of biotechnology or pharmaceutical related experience in a clinical development leadership role; a mix of corporate and academic experience acceptable, although the time spent in a corporate setting must be both significant and have been proven impactful
  • Adaptability, flexibility, independence, and resourcefulness; willing to roll-up-sleeves and multi-task essential to thriving in a small company environment
  • Proven clinical development strategist with experience designing and conducting clinical trials, with experience in all phases of clinical development (Phases 1-3).
  • Exceptional experience in Early Clinical Development, including translational pharmacology and biomarkers, driving programs from First-in-Human through Proof-of-Concept
  • Highly skilled in delivering programs and protocols that meet company specified targets and project objectives
  • Experience in the areas of Renal, Metabolism, and/or Cardiovascular is preferred.
  • Must be a highly effective communicator who is able to establish collaborative internal/external working relationships, present ideas clearly and be perceived by others as approachable and accessible
  • Proven ability to think strategically and demonstrate expertise in developing and implementing strategies, policies, and plans
  • Demonstrated ability to develop and maintain excellent working relationships with both internal colleagues and external contacts, including key opinion leaders, investigators, and patient advocacy groups

The expected salary range for this role for employees located in the San Francisco bay area is $306,000 - $318,500. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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