The Position:

Are you ready to take the helm of discovery efforts in our DMPK group at Maze? As an Associate Director, you'll be at the forefront of driving our mission forward, supporting discovery projects from hit-to-lead (H2L) through investigational new drug (IND) phases. Your expertise will be paramount as you collaborate with various teams within Maze, designing and executing specialized studies to unravel the intricacies of drug metabolism and pharmacokinetics. Serving as the voice of DMPK on cross-functional project teams, you'll play a pivotal role in shaping the future of our groundbreaking medicines. And as a mentor within our team, you'll have the opportunity to inspire and guide the next generation of scientists. Reporting directly to the Head of DMPK, you'll have the support and guidance needed to excel in this dynamic role. A specialized background in advanced drug metabolism concepts (e.g. met ID, enzyme kinetics) and/or PK modeling is ideal and opportunities to implement and further develop this skill set will be presented.  Join us in this journey of discovery and innovation, where your impact will be felt in every breakthrough we achieve.

Your Impact:

  • Lead and manage the discovery efforts of the Maze DMPK group.
  • Collaborate with various teams at Maze to design and execute specialized studies aimed at addressing specific DMPK-related questions and determining PK/PD relationships.
  • Serve as the DMPK representative on cross-functional discovery project teams.
  • Mentor scientists and associates within the DMPK group.
  • Oversee projects conducted with CRO partners.

Skills and Qualifications:

  • PhD in a relevant field with 6+ years of experience in DMPK within a biotech or pharmaceutical company, including proficiency with LC-MS systems.
  • Proven experience independently representing DMPK in cross-functional project teams, particularly during clinical candidate selection and IND-enabling phases.
  • Strong general knowledge of pharmacokinetics and drug metabolism concepts, coupled with an advanced skillset in one or more specialized areas.
  • Demonstrated expertise with Phoenix WinNonlin, PK modeling, and human PK predictions.
  • Excellent communication and writing skills, with the ability to thrive in a team-based environment.
  • Detail oriented with strong analytical skills.

As an Associate Director, we also expect our leaders to demonstrate the following Leadership Competencies: 

  • Communication and Influence
    • Communicates the reasoning behind decisions to appropriate stakeholders.
    • Promotes open communication with internal and external stakeholders.
    • Fosters healthy and respectful debate.
  • Teamwork and Collaboration
    • Creates opportunities for team members to connect with others outside of team.
    • Manages conflict effectively between teams.
    • Openly values thoughts, opinions, and contributions of employees.
  • Execution and Results
    • Exercises astute judgment to make decisions with only the necessary amount of data.
    • Supports team members in creating their own resolutions to challenges and problems.
    • Works with other to reinforce process compliance, what good looks like, and risk mitigation.
  • Develop Others and Self
    • Articulates what good looks like throughout Maze.
    • Pursues development activities for continuous improvement of self and team.

Join us at Maze as we embark on this exciting journey to revolutionize medicine. If you're ready to make a significant impact and contribute to groundbreaking discoveries, apply now for the position of Associate Director, DMPK.

About Maze Therapeutics

Maze Therapeutics is a biopharmaceutical company that is harnessing the power of human genetics to transform the lives of patients, with a focus on genetically informed therapies for common diseases,  such as chronic kidney disease, . and seeks to focus expertise and resources towards underserved communities. Maze applies variant functionalization in tandem with advanced data science methods and a robust suite of research and development capabilities to advance a pipeline of novel precision medicines. Maze has developed the Maze Compass Platform™, a proprietary, purpose-built platform to understand and integrate the critical step of variant functionalization into each stage of drug development. Utilizing the Maze Compass Platform™, Maze is building a broad portfolio of wholly owned and partnered programs. Its two lead programs are focused in Chronic Kidney Disease (CKD), a condition that impacts an estimated 37m individuals. The first program in CKD addresses a genetic subset of the common disease that has a disproportionate impact on the Black Community. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission. 

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $185,700 to $227,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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