Manifold Bio is a biotech company pursuing a pipeline of protein therapeutics using novel molecular measurement technologies and library-guided protein engineering. Our drug discovery engine is differentiated by massively parallel screening in vivo from the beginning of our discovery process. This unique platform is powered by a proprietary protein barcoding technology that allows multiplexed protein quantitation at unprecedented scale and sensitivity. We combine this and other high-throughput protein engineering approaches with computational design to create antibody-like drugs and other biologics. Our world-class team of protein engineers, biologists, and computational scientists are working together to aim the platform at therapeutic opportunities where precise targeting is the key to overcoming clinical challenges.

Position

 

We are seeking a scientist excited to join a creative, fast-paced, and collaborative team. Together, we’ll build multiplexed protein quantitation technologies that massively increase the throughput of testing protein therapeutic designs and fundamentally change the current paradigm of drug development. The ideal candidate will have deep technical expertise in protein and/or molecular biology and a track record of  designing and executing experiments. Experience in learning, deploying, and inventing new methods would additionally be valuable. You will work directly with the CSO to define, execute, and iterate on projects and help build out an interdisciplinary team of scientists and engineers.

 

Responsibilities

 

  • Develop novel protein engineering platform technologies
  • Design and clone DNA libraries of synthetic proteins at megascale efficiency
  • Leverage NGS technologies to measure millions of variants 
  • Apply the protein measurement platform to application areas both in vitro and in vivo
  • Build out the lab and experimental workflows in a way that optimizes productivity and efficiency

 

Required Qualifications

 

  • PhD or equivalent experience in protein and or molecular biology, biological engineering or a related field
  • Experience with assay development and optimization (ideally in library/screening context)
  • 5+ years hands-on molecular biology wet lab experience
  • Collaborative, curious, flexible, and strong communication skills
  • A deep passion for science and developing new methods

 

Why you might be a good fit

 

  • Experience with DMS, MPRA, CRISPR screening, cancer screens, single cell sequencing, or any other screening-based method with an NGS readout
  • Experience designing or working with libraries of DNA, protein, gRNAs, or promoter regions to assay in  multiplex 
  • Experience with phage/yeast/mammalian display or similar
  • Experience with Flow/FACS-based quantitative assays
  • Experience with protein assays, e.g. production, purification, QC, Chromatography (Affinity, Size, Ionic etc) and detection (PAGE/ELISA/Blots), in high throughput context

Benefits

 Highly competitive additional benefits package across healthcare, paid time off, commuter benefits, and company-provided lunch every day.

 

We value different experiences and ways of thinking and believe the most talented teams are built by bringing together people of diverse cultures, genders, and backgrounds.

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