Caribou is a leading clinical-stage CRISPR genome-editing biopharmaceutical company founded by pioneers in this field. Leveraging our proprietary technologies, we are developing genome-edited, off-the-shelf immune cell therapies for the treatment of patients with devastating human diseases, including cancer. We believe that cell therapies are critical now and for the future of cancer therapeutics, and that advanced genome editing is necessary to develop sophisticated cell therapies to treat a variety of malignancies. We are developing a pipeline of wholly-owned, genome-edited, off-the-shelf CAR-T and CAR-NK cell therapy product candidates for a range of tumor types. Caribou’s headquarters are in Berkeley, California.
Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, their contributions are recognized, and their needs are met.
As a result of exciting developments both with Caribou’s internal pipeline programs and with the addition of a significant external partnership, we have multiple early-stage projects focused on the preclinical discovery and development of CAR-T cell therapy candidates.
We are seeking a Scientist/Senior Scientist to join our Technology Development group. Working in a collaborative environment, you will work to advance and develop novel technologies to enhance the cytotoxicity, proliferation, and persistence of Caribou’s cell therapy products. This is an opportunity for a talented scientist to drive creative discovery and Caribou’s next-generation cell therapy programs.
- Working with a matrixed team to develop and advance preclinical allogeneic CAR-T cell programs targeting liquid and/or solid tumors
- Designing, coordinating, executing, and analyzing in vitro and in vivo experiments
- Thinking creatively, proposing, and implementing innovative cell engineering approaches to expand Caribou’s preclinical pipeline and intellectual property
- Communicating results clearly and concisely internally and externally
- Keeping accurate records of experiments and results
- Mentoring and supporting team members
- PhD in cell biology, molecular biology, immunology, or a closely related field
- Minimum 3 years of relevant postdoctoral experience (academic or industry)
- Hands-on proficiency in Genome editing, primary cell isolation mammalian cell culture, and developing and performing cell based assays (such as cell activation, proliferation, cytotoxicity and phenotype characterization)
- Proficiency in a broad range of molecular genetics and cell biology techniques
- Experience in planning and executing in vitro functional assays
- Proven track record of problem solving and the ability to adapt and integrate new technologies into existing projects
- Highly organized with excellent communication and critical thinking skills. Self-motivated with a strong collaborative mindset
- Ability to develop and mentor a team of researchers
- Comfort in a fast-paced environment and ability to adjust workload based upon changing priorities
- Prior experience with cell therapies or other biologics
- Experience with Next-Generation Sequencing (NGS) platforms
- Experience in multi-parameter flow cytometry and data analysis
- Familiarity with immune cell signaling pathways governing immune response, proliferation, differentiation, and metabolism
- Experience designing and performing genetic engineering on cultured mammalian cells
- Work in pharmaceutical or biotechnology company focused on immuno-oncology
- Understanding of regulatory guidelines for cell therapies
- First author publications in related discipline
Caribou compensation and benefits include:
- Comprehensive compensation package, which includes stock options and an employee stock purchase program for all employees
- Generous paid vacation time, in addition to company-observed holidays and floating holidays
- Excellent medical, dental, and vision insurance
- 401(k) retirement savings plan, which includes matching employer contributions
- Tuition reimbursement program
Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.
Caribou requires employees to be fully vaccinated, including a booster shot, against COVID-19 unless they have an approved medical or religious accommodation. Proof of such vaccination will be required as part of the hiring process.
For more information about Caribou, visit www.cariboubio.com and follow the company @CaribouBio.