We create shielded stem cell transplants that enable targeted therapies to attack only cancer cells

Every year, thousands of patients with Acute Myeloid Leukemia (AML) and other blood cancers relapse post-transplant with no safe and effective treatment options. Vor Bio’s approach provides the first opportunity to deliver potentially curative treatments post-transplant.

Our novel platform creates a shielded stem cell transplant that is designed to enable multiple modalities and therapies, including Antibody Drug Conjugates (ADCs) and Chimeric Antigen Receptor T (CAR-T) cells, which could potentially be effective against the tumor, but are toxic to normal cells. Vor’s genetically engineered transplant provides a protective shield to the healthy cells and thereby allows the cancer cells to be specifically targeted for destruction.

By shielding healthy cells, Vor Bio is aiming to potentially cure Acute Myeloid Leukemia (AML) and other blood cancers. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine’s greatest challenges.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines

Fellowship: Fostering genuine bonds of collaboration and mentorship

Humility: Acting selflessly by putting the collective mission first

Who we are looking for:

Vor Bio is seeking an Associate Director/ Director of Process Development who will be a key member of the Process and Analytical Development group. The successful candidate will be overseeing the design, development, and characterization of gene edited hematopoietic stem cells (eHSC) and CAR-T manufacturing processes to support early and late phase clinical trials. The successful candidate will have a broad understanding of cell therapy manufacturing, and familiarity with manufacturing of critical/ancillary reagents.  The ideal candidate will possess significant experience and skills in people/project management and cross functional collaboration.

Key areas of responsibility:

  • Oversee all aspects of Process Design for HSCs and CAR-T:  optimize cell therapy manufacturing process, execute process characterization, author process control strategy, and support process validation
  • As necessary, provide support for the development, characterization, comparability, and validation of critical starting material manufacturing processes, e.g., Cas9, gRNA, and lentiviral vector production
  • Establish strong collaborative relationships and represent Process Development function across the organization and with external partners
  • Author and review technical reports, regulatory documents, and patents as necessary
  • Champion a “protocol-driven” and “report results” methodology
  • Maintain and foster a positive, supportive, and collaborative team culture

Qualifications:

  • PhD in the pertinent life sciences or engineering, with 10+ years relevant experience
  • Excellent cross-functional communication skills
  • Expertise (5-7+ years) leading process development of HSC and/or CAR-T products
  • Process development experience in late-stage program is highly desired
  • Understanding of cGMPs and demonstrated experience leading groups with substantial contributions to regulatory filings
  • Understanding of manufacturing processes for genome editing reagents including Cas9, gRNA, lentiviral vectors
  • Demonstrated track record of consistently meeting deadlines in a dynamic, fast-paced environment
  • Experience in process characterization and validation is a plus

By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

Please visit our website at https://www.vorbio.com/ for more information.

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