We make healthy cells invisible to targeted therapies

Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.

At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.

These eHSCs give rise to generations of new healthy blood cells that are effectively invisible to targeted therapies. Diseased cells displaying the target protein and are then vulnerable to attack. This process potentially broadens the therapeutic window and improves the utility of complementary targeted therapies.

What we value in our fellow Voracians

Passion: Enthusiastically driving our science toward innovative medicines

Fellowship: Fostering genuine bonds of collaboration and mentorship

Humility: Acting selflessly by putting the collective mission first

 

Who we are looking for:

Vor Bio is seeking a Computational Biologist to join our growing quantitative biology team. The successful candidate will work onsite with a group of multi-disciplinary scientists and apply computational approaches and data sciences expertise to support the development of innovative cell and gene therapy products. 

Key areas of responsibilities

  • Perform analyses of cutting-edge genome editing therapeutics data and partner with research and development teams to support genome engineering programs.
  • Develop, maintain, and standardize bioinformatics pipelines using workflow management tools and scale the analysis with AWS cloud
  • Contribute to all aspects of target discovery and validation including but not limited to strategy development and planning, tool development and execution of individual projects
  • Work with regulatory authorities to standardize the bioinformatics workflow inhouse and prepare scientific study reports for regulatory submission

Qualifications:

  • Ph.D. and 1+ years of academic/industry experience in Bioinformatics, Computational Biology, Genomics, or other related fields
  • Fluent in programing languages Python, Bash scripting, and R
  • Demonstrated experience in developing bioinformatics tools/pipelines is required
  • Experience working in the cloud environment (AWS) and Docker-based deployment
  • Experience analyzing gene editing NGS assays for on-target/off-target prediction and assessment is preferred
  • Excellent verbal and written communication skills
  • Enjoy working in a multi-disciplinary team to achieve project goals
  • Must be able to work in the Vor Bio office regularly

 

By becoming a team member here at Vor, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in
Cambridge with easy access to public transportation and ample parking.

As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

In an effort to protect our coworkers and communities from COVID-19, where permitted by law Vor Biopharma Inc. requires all employees to be fully vaccinated against COVID-19 and up to date with their vaccination unless they receive an approved reasonable accommodation for medical or religious reasons.

Please visit our website at https://www.vorbio.com/ for more information.

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