Vir Biotechnology, Inc. is a clinical-stage biopharmaceutical company focused on powering the immune system to transform lives by discovering and developing medicines for serious infectious diseases and cancer. Vir’s clinical-stage portfolio includes infectious disease programs for chronic hepatitis delta and chronic hepatitis B infections, in addition to multiple oncology programs. Vir also has a preclinical portfolio of programs across a range of other infectious diseases and oncologic malignancies. 

We believe the success of our colleagues drives the success of our mission. We are committed to creating a company passionate about equality, inclusion, and respect. When everyone feels supported and encouraged to give their best, we will collectively deliver outstanding results.

THE OPPORTUNITY

Vir Biotechnology is looking for an enthusiastic Senior Scientist in LCMS Peptide Quantitation accountable for ensuring development and execution of discovery to preclinical peptide quantitative assays. You will be involved in strategic planning and development of assays featuring quantitative measurement of peptides both from in-vitro and in-vivo sources.  These assays support discovery, development and pharmacokinetics of conditionally activated biologics including T cell engagers and cytokines. You will lead technical collaboration and planning with internal cross-functional teams and represent Vir as a subject matter expert in modern peptide quantitation methods using LCMS.

You will report to the Senior Director, Research Oncology.

This role is located in our San Francisco headquarters with an expectation of at least 4 days per week in office.

WHAT YOU'LL DO

  • Chromatography and mass spectrometry method development for peptide quantitation in support of discovery, development and pre-clinical studies (PK). 
  • Generation of workflows using Data Independent-analysis/SWATH; Parallel Reaction Monitoring (or MRMHR); Multiple Reaction Monitoring, as well as Data-independent analyses for peptide quantitation including the optimal use-case for each workflow. 
  • Perform proteolytic digestion of proteins for LCMS analyses. 
  • Perform protein immunocapture/affinity purification from biological matrices such as plasma or serum. 
  • Perform sample cleanup and purification for LCMS. 
  • Work cross-functionally with members of other departments to complete tasks when required. 
  • Write development reports, SOPs, and contribute to writing of relevant sections in IND submissions to regulatory authorities. 
  • Manage externally facing interactions and occasionally acting as a subject matter expert for the outsourcing of in-house developed methods (sample analysis and method: transfer, development, and validation oversight). 

WHO YOU ARE AND WHAT YOU BRING

  • A minimum of a Bachelor's degree in a scientific discipline with 10+ years of work experience, Master’s degree with 8+ years or Ph.D. with 5+ years of industry work experience.  
  • Experience with LC./MS-MS is required 
  • Experience developing hybrid immuno-capture LC-MS methods. 
  • Experience and understanding with successful implementation of bioanalytical methods per current regulatory guidance and expectations is beneficial. 
  • Experience with transfer of assays internally and externally is beneficial. 
  • Experience working in a GMP or GLP environment is desirable. 
  • Self-motivated to carry out both new and routine tasks. 
  • Contribute to discovery and development by identifying opportunities and supporting continuous improvement. 
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WHO WE ARE AND WHAT WE OFFER

The expected salary range for this position is $151,000to $199,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors.

Vir’s compensation and benefits are aligned with the current market and commensurate with the person’s experience and qualifications. All full-time employees receive a package that includes: compensation, bonus and equity as well as many other Vir benefits and perks such as: health, dental, vision, life and disability insurance benefits, non-accrual paid time off, company shut down for holidays, commuter benefits, child care reimbursement, education reimbursement, 401K match and lunch each day in the office.

Applicants must currently be authorized to work for any employer in the U.S.  We are unable to sponsor or take over sponsorship of an employment Visa at this time.

Vir Biotechnology (“Vir”) is an equal opportunity employer.  All employment decisions at Vir are based on legitimate, non-discriminatory business requirements, job duties and individual qualifications. Employment decisions are made without regard to race, color, religion, sex (including pregnancy), gender, gender identity, gender expression, sexual orientation, age, parental status, marital status, national origin, ancestry, disability, medical condition, genetic information (including family medical history), political affiliation, military service or any other legally protected characteristic. 

This commitment extends to all management practices and decisions, including recruitment and hiring, compensation, appraisal systems, promotions, training and career development programs.  Vir also strongly commits to providing employees with a work environment free of unlawful discrimination or harassment.

Vir Human Resources leads recruitment and employment for Vir. Unsolicited resumes sent to Vir from recruiters do not constitute any type of relationship between the recruiter and Vir and do not obligate Vir to pay fees should we hire from those resumes. We ask that external recruiters and/or agencies not contact or present candidates directly to our hiring manager or employees.

For hires based in the United States, Vir Biotechnology, Inc., participates in E-Verify.

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