The Role:

We are looking for a computational biologist/biostatistician/bioinformatician to support ongoing clinical trial-based microbiome data analysis and assist in mathematical modeling and statistical analysis of biological datasets towards the development of Vedanta Biosciences’ portfolio of Live Biotherapeutic Products (LBPs) based on defined bacterial consortia. Vedanta is developing defined bacterial consortia to treat intestinal pathogen infections, cancer, allergy, and inflammatory bowel diseases. The candidate will work with members of the Systems Biology team to address clinically significant research questions, define the pharmacokinetics and pharmacodynamics (PK/PD) of LBPs in clinical studies, and investigate microbiota or immune biomarkers of LBP treatment and health-related phenotypic outcomes. We are looking for an individual who is independent, curious, self-motivated, excited to collaborate and an excellent communicator. The job title and level will correspond to the experience and skills of the selected candidate.

 

Here’s What You’ll Do:

  • Conceptualize and perform pharmacokinetic and pharmacodynamics (PK/PD) analysis of LBPs in clinical microbiome studies.
  • Implement multivariate statistical models to extract associations from translational medicine, pre-clinical and clinical microbiome datasets. Curate, visualize and communicate analysis results.
  • Identify biomarkers that can impact drug development decisions by mining Vedanta’s clinical datasets and using knowledge of disease biology, microbiome science, drug pharmacology, and clinical endpoints.
  • Create statistical pre-processing workflows to control structural bias in microbiome data
  • Develop methods for phenotype prediction using mechanistic tools and supervised machine learning.
  • Study interactions among consortia member strains, the resident microbiota, and the host using dynamical models

 

Requirements:

  • MS/PhD in bioinformatics, computational biology, biological physics, data science or related quantitative field with 3+ years of working experience in quantitative statistical or mathematical modeling.
  • 4+ years of experience in a statistical programming language, such as R or Python are required.
  • Experience with quantitative statistical and informatics methods including multivariate regression, mixed effects modeling, supervised and unsupervised machine learning tools including random forest, logistic regression, genome mining, or other related methods is required.
  • Analytical experience with clinical trial data is highly desirable.
  • Analytical experience with microbiome and microbial community ecology datasets is highly desirable.
  • Experience with building reproducible data analysis workflows is required.
  • Highly organized and motivated individual. Must be a team player, able to work well in a group setting as well as independently in a fast-paced environment.
  • Strong communication and presentation skills are required.

 

Why join Vedanta Biosciences

Vedanta is pioneering the development of a new class of therapies based on defined bacterial consortia that act by modulating the human microbiome. Modulation of the human microbiota holds enormous promise to treat a broad range of immune and infectious diseases in ways that are completely different to existing drug classes. Breakthrough discoveries of our scientific team in the field of mucosal immunology have led to the first rationally designed drug candidates in the microbiome field.

We invite you to explore our site to learn more about our company and how our discovery platform enables identification of bacterial consortia with drug-like properties and their manufacture to GMP standards.

Our Vision:
We are harnessing the human microbiome to enable a new drug modality based on rationally defined bacterial consortia

Vedanta is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Vedanta will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Apply for this Job

* Required
  

U.S. Equal Opportunity Employment Information (Completion is voluntary)

Individuals seeking employment at Vedanta Biosciences are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information in order to help us comply with federal and state Equal Employment Opportunity/Affirmative Action record keeping, reporting, and other legal requirements.

Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.


Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.