Variant Bio is a Seattle-based biotech company entering a rapid growth stage having recently closed a $100mm+ Series B. The company was started because we believe that human genetics has the power to transform drug development. We are working towards developing therapies to improve global health by studying the genes of people who are outliers for medically relevant traits. To facilitate this, we have built proprietary genomics and phenotyping platforms that allow us to dramatically reduce the cost of genomic studies and identify genetically-validated targets for therapeutic development.

All of our studies are co-designed with local partners: community groups, academics, and hospitals around the world, and we built Variant Bio from the ground up with ethics at its foundation. We recognize the contribution of our partners through an industry leading benefit-sharing program that dedicates 4% of our revenue and equity value to support local healthcare, sustainable development, education, research, and capacity-building initiatives.

Variant Bio is an equal opportunity employer that guarantees a work environment that respects and values diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status.

Job Description

We seek a passionate and innovative individual with experience in functional genomics and human genetics to help build and lead Variant Bio’s new Translational Genomics team. This team will be composed of both experimental & computational scientists and will be responsible for translating computationally derived genetic associations into actionable therapeutic targets. The ideal candidate will be expected to not only have experience with a broad range of functional genomics techniques, but also in the design and execution of preclinical assays with high human translatability. Since we are an actively growing start-up, we also seek creative thinkers, agile learners and candidates with an unwavering willingness to do what is necessary to help build the company and mature a human-genetics-backed therapeutic pipeline. Our current disease areas of interest include kidney disease, liver fibrosis, inflammation, and neurodegenerative disorders.

Responsibilities

  • Build a world-class translational genomics team and capability for the company.
  • Design and optimize an approach to translate human genetic and molecular associations into actionable therapeutic hypotheses.
  • Work closely with our computational genetics team to generate testable hypotheses and prioritize associations from their analyses of human studies. 
  • Partner with our disease area teams to develop assays and model systems to identify or test hypotheses around genetic targets.
  • Serve as a leader in R&D and work collaboratively across the organization to help deliver new targets for drug discovery programs.
  • Recruit top talent into the company and serve as an internal mentor to junior scientists.
  • Serve as an external champion of the company

Qualifications

  • A Ph.D. in a biological discipline with at least 5 years of relevant experience in either an industry or academic setting and an outstanding reputation in your field. 
  • Deep understanding of both the computational and experimental approaches to translating human genetic and molecular associations into valuable drug targets; including but not limited to: functional genomics screening technologies, CRISPR and other gene editing approaches, RNAseq and other preclinical omics experiments and analyses, 2D and 3D imaging.
  • Familiarity with the process by which therapeutics and/or diagnostics are discovered and developed.
  • Familiarity with publicly available databases and user interfaces for the investigation of genetics, biology and human disease data.
  • Experience leading and mentoring teams of scientists; an ability to recruit top talent.
  • Strong people skills with an ability and willingness to work on a multidisciplinary R&D team.
  • Independent, creative, detail-orientated, and a critical thinker. 
  • Disease area, public health, genetics or human adaptation expertise is an advantage.   
  • Compelled by the company’s mission of great science, a strong ethical stance, and benefit sharing.

Perks

  • Opportunity to be part of an early-stage startup entering a rapid growth phase.
  • Competitive, industry leading salary, and comprehensive benefits including medical, dental, vision, short and long term disability and life insurance.
  • 401(k) plan that includes an automatic 3% employer contribution.
  • Centrally located in Seattle’s Eastlake neighborhood in a new Alexandria building with modern facilities, including a gym.

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