Variant Bio is a Seattle-based biotech company entering a rapid growth stage having recently closed a $100mm+ Series B. The company was started because we believe that human genetics has the power to transform drug development. We are working towards developing therapies to improve global health by studying the genes of people who are outliers for medically relevant traits. To facilitate this, we have built proprietary genomics and phenotyping platforms that allow us to dramatically reduce the cost of genomic studies and identify genetically-validated targets for therapeutic development.

All of our studies are co-designed with local partners: community groups, academics, and hospitals around the world, and we built Variant Bio from the ground up with ethics at its foundation. We recognize the contribution of our partners through an industry leading benefit-sharing program that dedicates 4% of our revenue and equity value to support local healthcare, sustainable development, education, research, and capacity-building initiatives.

Variant Bio is an equal opportunity employer that guarantees a work environment that respects and values diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status.

Job Description

We seek an exceptionally collaborative scientist or senior scientist with experience in translating genetic associations into actionable therapeutic targets to be part of a truly integrated R&D team. The ideal candidate will not only have experience with a range of experimental tools and techniques employed to discover and develop human therapeutics and biomarkers, but also have experience working right alongside geneticists and computational biologists to drive toward a common goal.  Since we are an actively growing start-up, we also seek creative thinkers, agile learners and candidates with an unwavering willingness to do what is necessary to help build the company and mature a human-genetics-backed therapeutic pipeline. Our current disease areas of interest include kidney disease, fibrosis, inflammation, and neurodegenerative disorders.

Responsibilities

  • Lead therapeutic programs from inception through to the clinic, with a focus on early-stage target prioritization and experimental validation.  
  • Establish and develop human translational models using human primary cells (e.g. organotypic/organoid cultures) relevant to our disease areas of interest. 
  • Become a disease and biology subject matter expert in a variety of areas, ready to tackle new genetic findings in diverse areas.  
  • Establish and employ technical methods to link disease-causing genetic variants to their relevant genes, cell types, molecular pathways and disease phenotypes.
  • Contribute to deep dives into our primary disease areas of interest and GWAS-identified targets to help build and support a competitive R&D pipeline.  
  • Work together with internal computational geneticists to advance genetic findings.  
  • Effectively communicate scientific results to internal and external audiences.
  • Contribute to scientific publications.

Qualifications

  • A Ph.D. in a biology discipline with >5 years of relevant experience.  Industry experience is a plus.   
  • A desire to be at the bench employing cutting-edge techniques, with the ability to grow a team and manage direct reports as our team grows.  
  • Familiarity with the process by which therapeutics are discovered and developed.
  • Expertise in the culture and experimental manipulation of human translational models of disease, e.g. organoid models, organ-on-a-chip, precision cut tissue slices, etc.  
  • Familiarity with publicly available databases and user interfaces for the investigation of genetics, biology and human disease data.
  • Experience using molecular characterization and functional studies, including CRISPR/gene editing, to understand the role of a gene in a disease is preferred.  
  • Strong people skills and an ability & willingness to work on a multidisciplinary R&D team.
  • Independent, creative, detail-orientated, and a critical thinker. 
  • Immunology, fibrosis, kidney disease or genetics expertise is an advantage.   
  • Compelled by the company’s mission of great science, a strong ethical stance, and benefit sharing.

Perks

  • Opportunity to be part of an early-stage startup entering a rapid growth phase.
  • Competitive, industry leading salary, and comprehensive benefits including medical, dental, vision, short and long term disability and life insurance.
  • 401(k) plan that includes an automatic 3% employer contribution.
  • Centrally located in Seattle’s Eastlake neighborhood in a new Alexandria building with modern facilities, including a gym.

Apply for this Job

* Required