Job Title: Senior Director, Early Discovery Chemistry

This role can be based in either Branford, CT or Lexington, MA.

About Us

Valo Health (formerly Integral Health) is a technology company applying human and machine intelligence to accelerate the creation of life-changing medical treatments. At the core of this vision is Valo’s computational platform: an end-to-end, integrated drug discovery and development engine that is being built from the ground up.

Valo hires the best and gives them first-class training and support. If you’re driven to perform, you’ll fit right in! We approach our work fearlessly, learn quickly, improve constantly, and celebrate our wins. A centerpiece of our culture is our commitment to inclusion across race, gender, age, religion, identity, and experience. Diversity fuels the Valo experience and drives us every day. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

About the Role

Valo developed a powerful Early Discovery Platform which combines the power of internal DEL and HTS libraries with our proprietary AI platforms to identify the best possible starting points for our Drug Discovery Programs.  We also leverage our automated chemistry platform for library construction and rapid expansion of hit series. We are seeking a creative and highly motivated individual to lead our Early Discovery Chemistry Team. This position is a leadership role reporting to the VP of Early Discovery and Technology with responsibility for multiple aspects of Early Discovery, DEL, HTS, lead generation, hit-to-lead, and lead optimization.

You’ll do…

  • Provide active leadership of the Early Discovery Chemistry team responsible for DEL chemistry and automated chemistry platforms as well as hit identification and hit to lead chemistry.  
  • Drive novel chemistry concepts, continuously innovate to enhance our capabilities in all aspects of Early Discovery Chemistry
  • Be a key member of the Early Discovery and Technology leadership team to drive overall strategy and capabilities
  • Have accountability for the activities of a team of experienced DEL chemists at a contract research organization, in addition to the internal team that also builds libraries
  • Actively participate in multidisciplinary project teams that focus on the identification, generation, and progression of chemical matter for drug targets from hit identification through to the clinic
  • Effectively interact with colleagues in biology, biochemistry, computational and medicinal chemistry, and other functional groups
  • Champion hit follow-up strategies and the synthesis of lead molecules
  • Drive library expansion for both DEL and HTS to expand diversity coverage to deliver drug-like molecules

You Bring…

  • PhD in chemistry with at least 10+ years or M.S./B.S. in chemistry with at least 15+ years of proven synthetic organic chemistry laboratory experience in the pharmaceutical or biotech industry  
  • 5+ years of Early Discovery chemistry experience; DEL and High Throughput chemistry experience is a significant advantage
  • Expert in small molecule drug discovery with experience from Hit ID to Lead Optimization and externally recognized through publications, patents and presentations
  • Dynamic and creative individual with strong problem-solving abilities
  • State-of-the-art knowledge of technologies, processes, and best practices, and consistent contribution to organic chemistry/medicinal chemistry/DEL scientific and patent literature
  • Excellent project leadership skills, work well in a team, are objective-driven, and understand the importance of project timelines
  • Track record of managing a large body of high quality technical and scientific results in a dynamic environment 
  • Experience designing and building targeted screening small-molecule libraries (DEL & Traditional)
  • Practical knowledge of the use of in vitro ADMET and in vivo PK to support lead generation and optimization would be a significant advantage
  • A proven manager who has hired, trained, motivated, facilitated and led teams in a manner that has positively impacted results, culture and strategic direction
  • Strong skills in developing the careers of direct reports
  • Excellent verbal and written communication skills with the ability to respectfully engage and collaborate across functional teams. 
  • Attention to detail and a passion for drug discovery.

More on Valo

Valo Health is a privately held company founded by David Berry, a General Partner at Flagship Pioneering who has founded over 30+ leading companies across life sciences, technology, and sustainability with three companies valued at >$3B+ including Indigo Agriculture, the #1 on the CNBC Disruptor list and ~15 IPOs and acquisition. David was instrumental in creating Flagship VentureLabs, which is where the Firm's 100+ companies - worth more than $38B in aggregate value - have been conceived, incubated and launched. In addition, David has been broadly recognized as a world-leading innovator: elected as a Young Global Leader by the World Economic Forum, named as Innovator of the Year by Technology Review from amongst its Annual TR35 list, and selected as one of 12 Innovators Reshaping Reality by the U.S. State Department, alongside pioneers such as Tim Berners-Lee. David and his companies have been awarded with over 150 additional awards and honors and he holds over 200 patents and patent applications. David currently serves on the United Nations Sustainable Development Solutions Network (UN SDSN), where he was a Founding Leadership Council Member.    

Apply for this Job

* Required


U.S. Equal Opportunity Employment Information (Completion is voluntary)

Individuals seeking employment at Valo Health are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information in order to help us comply with federal and state Equal Employment Opportunity/Affirmative Action record keeping, reporting, and other legal requirements.

Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.