Programmable DNA, the software of Life, is finally here! Twist Bioscience is developing a disruptive Synthetic DNA technology that will change the world, enabling widespread health and sustainability. Synthetic biologists will use our products to engineer how organisms produce cures to diseases, make everyday chemicals by using the atmosphere as the carbon source, enable plants to make their own fertilizers, and to create in-vivo diagnostics that alert us when we are sick, and many more applications.

We are looking for motivated and enthusiastic individuals to join our Twist Bioscience Operations Team in Wilsonville, near Portland, Oregon. The ideal candidate will be driven and will do what it takes to keep synthetic biology manufacturing on track in a fast-paced start-up environment. 

The Gene Manufacturing Supervisor will be very knowledgeable of basic synthetic/molecular biology skills (PCR, vector production, cloning, miniprep, DNA analysis, sequencing, packaging) and will perform, train and/or oversee the production staff on basic molecular biology workflows in a highly automated, high-throughput manner. He or she will be responsible for the manufacture and analysis of a variety of custom gene products across Twist Bioscience’s proprietary workflow. The Manufacturing Supervisor will be the main point of contact for shift operators. He or she will assure the staff is working according to the plan of record, will provide guidance, make decisions on priorities and troubleshooting.

The Manufacturing Supervisor will also be responsible for leading the pass down of information between shifts.

The ideal candidate will work independently, be very neat and organized, have excellent molecular biology skills, maintain and build 5S systems, contribute to process improvement, and documentation, and communicate effectively with peers and management. Knowledge of good laboratory practices (GLPs) and familiarity working in GMP or ISO rated production is necessary.

What You’ll Be Doing

  • Manufacturing high-quality custom gene products in a high throughput MFG molecular biology lab according to established SOPs.
  • Thoroughly maintaining accurate and detailed documentation of all work performed, batch records
  • Operating basic as well as automated lab equipment for molecular biology workflow.
  • Tracking the quality metrics by both physical and functional test methods. Initiating any corrective actions necessary to bring production back to expected standards.
  • Exercising keen observational skills to proactively identify production problems, then leading technical discussions to provide solutions. Including issues involving lab techniques, protocols, processes and handling of product and equipment.
  • Upholding standards as defined by the manufacturing process.
  • Supporting continuous cost/process improvement initiatives.
  • Promoting and prioritizing a safe work environment.
  • Maintaining and calibrating lab equipment.
  • Leading shift pass-down efforts and prioritizing work to be done.
  • Taking accountability for the shift when senior personnel are not on site.
  • Acting as advisor to meet schedules and/or resolve technical problems and provides production guidance to junior MFG personnel.
  • Scheduling of staff.
  • Reviewing and verifying production batch records and manufacturing documents.
  • Writing and submitting incident reports, CAPAs, planned deviations etc.
  • Following regulatory and ISO 13485 requirements.

What You’ll Bring to the Team

  • S. or B.S. in Biology, Chemistry or Biochemistry.
  • 5 year minimum lab experience in manufacturing environment.
  • Thorough experience operating liquid handlers such as Hamiltons and Tecans.
  • Deep familiarity with molecular biology techniques such as PCR, cell-based cloning, DNA extraction and purification
  • Experience with sample tracking software such as LIMS/MES systems, especially when integrated with liquid-handling robots.
  • Experience working within a ISO, GMP, LEAN manufacturing environment.
  • Sharp data interpretation acumen.
  • A track record of delivering process improvements.
  • Laboratory management experience.
  • Outstanding communication skills and emotional intelligence.
  • Physical Requirements
  • Must be able to stand for long periods of time while performing duties.
  • Must be able to work safely with chemicals and hazardous materials.
  • Must be able to lift up to 20 lbs.
  • Must be able to work outside of regular work hours/work a flexible shift as needed.

Possible Shifts:

SHIFT 2A:  Saturday - Tuesday/ Sunday-Tuesday 7PM-7:30AM 12h day/ 3d /4d alt work week with 1 weekend day

SHIFT 2B:  Wednesday-Saturday / Wednesday-Friday 7PM-7:30AM 12h day/ 3d /4d alt work week with 1 weekend day



About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.



Apply for this Job

* Required

resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Twist Bioscience’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.