Twist Bioscience Corp. is an innovative synthetic biology company founded in April 2013 and headquartered in San Francisco, California. Twist is the first company to successfully marry small-scale engineering with biology to commercialize silicon-based production of high-fidelity, high-quality synthetic DNA, producing it faster, cheaper and more seamlessly than was previously possible. In a relatively short time since its formation, the company has established itself as the market leader with >300 employees and $285M of raised capital to date. 

Twist 生物科技公司是一家创新的合成生物学公司。Twist成立于 2013年4月, 总部位于加利福尼亚州旧金山。Twist 生物科技公司是第一家成功将小规模工程与生物学相结合的公司, 以更快, 更便宜和无缝的方式将硅基生产的高保真度和高品质合成 DNA 商业化。在相对较短的时间内, 公司已成为市场领导者, 迄今拥有超过300名员工和2亿8500万美元的募集资金。

Synthetic DNA has been used for more than five decades in a growing number of applications including drug development, vaccines and antibiotics, diagnostics, chemicals, agriculture and other industrial needs. It also has promise in novel applications like data storage. Twist is keen to leverage its high-quality synthetic DNA platform to grow its market potential by vertical integration of some of these applications.

合成 DNA 已经被使用超过五十年并在越来越多的应用中使用, 其中包括药物开发、疫苗和抗生素、诊断、化学品、农业和其他工业需要。它还具有数据存储的应用前景。公司利用其高质量的合成 DNA 平台, 通过垂直整合其中一些应用程序来发展其市场潜力。

Twist is now expanding to China with the establishment of Twist China as a Wholly Foreign-Owned Enterprise located in Guangzhou. We are looking for an outstanding candidate to fill our first R&D Research Scientist position in Twist China. As a member of the Twist R&D team, the candidate’s responsibilities include:

随着公司的扩展, Twist在中国广州成立了一家外资企业(外商独资)Twist China。公司也正在招聘优秀人才作为研发科学家。作为Twist研发团队的一员, 你的职责包括:

 

  • Help build Twist China’s R&D facility from the ground up.
  • 建立Twist在中国的研发部门
  • Collaborate with Twist San Francisco’s R&D team to develop custom DNA-based applications and assays for Synthetic Biology (SynBio) and Next-Generation Sequencing (NGS).
  • 与旧金山的研发团队合作, 为合成生物学(SynBio)和下一代测序(NGS)开发用户定制的基于 DNA的应用和测试
    • SynBio products include high-throughput gene synthesis, custom cloning, oligo pools, gene editing, and variant libraries.
    • SynBio产品包括高通量基因合成, 定制克隆, 寡核苷酸池, 基因编辑,突变文库等
    • NGS products include exome sequencing, custom target enrichment panels, library preparation, and other emerging application.
    • NGS产品包括外显子组测序, 定制靶向富集板块(panel), 文库制备、和其他新兴应用
  • Perform and support custom manufacturing of non-standard SynBio and NGS products, refining workflows and processes, scaling up production, and establishing routine production over time.
  • 执行和支持非标准的SynBio和NGS产品的定制生产, 改进工作流程, 扩大生产, 并建立常规生产
  • Transfer manual, semi-automated, and fully-automated workflows and processes developed by the Twist San Francisco R&D team to China.
  • 在中国建立由旧金山团队开发的手动,半自动和 全自动工作流程
  • Help establish Twist China’s production site, supporting technology transfer, establishing baseline production processes, scaling-up production, and supporting/troubleshooting day-to-day operations.
  • 协助建立中国生产基地, 包括技术转移、建立基线生产流程、扩大生产、支持日常操作和故障排除

 

Required Education and Experience:

  • PhD degree in Chemistry, Biology, Biochemistry, or a closely related field; or MS degree with a minimum of 5 years of work experience in R&D and process development, and a track record of high-quality work.
  • 具有化学, 生物, 生物化学, 或相关领域的博士学位; 或具有硕士学位并有5年以上的高质量研发和开发工作经验
  • Strong background in molecular biology techniques such as gene synthesis, molecular cloning, enzymatic assays, PCR/qPCR, and CRISPR/Cas9.
  • 具有分子生物学技术的强大背景, 包括基因合成、分子克隆、酶法测定、PCR/qPCR、CRISPR/Cas9 等
  • Direct experience with NGS and library preparation for NGS.
  • 具有NGS和NGS文库制备的工作经验
  • Direct experience with liquid handling systems and automation tools.
  • 具有使用液体处理系统和自动化工具(自动化液体处理工作站)的工作经验

 

Required Skills:

  • Excellent analytical and problem solving skills. Gather and analyze information masterfully; identify problems and use a combination of knowledge, intuition, and experience to solve problems in a timely manner.
  • 出色的分析和解决问题的能力。熟练地收集和分析信息; 识别问题并结合知识, 直觉和经验来及时解决问题
  • Excellent communication skills. Proficient in writing and communicating in English.
  • 良好的沟通能力。精通英语交流并写作
  • Able to present data effectively.
  • 可以有效地呈现数据
  • Excellent interpersonal skills. Respectful and open to others’ views; contribute to building a positive team spirit.
  • 良好的人际交往能力。尊重他人的观点; 建立积极的团队精神
  • Excellent documentation skills. Able to prepare documents including data summaries, technical and analytical reports, and transfer the procedures to manufacturing.
  • 出色的文档技能。能够准备文件, 包括数据总结, 技术和分析报告, 并将程序转移到制造
  • High attention to detail.
  • 高度注重细节
  • Comfortable working in a fast-paced environment.
  • 能够在一个快节奏的环境中工作
  • Self-motivated and passionate about your work.
  • 自我激励, 对工作充满热诚

 

Preferred Experience:

  • Industrial experience in SynBio or NGS companies is highly desirable.
  • SynBio和NGS公司行业经验
  • Experience in gene synthesis/assembly is highly desirable.
  • 基因合成/组装经验
  • Experience in NGS kit development is highly desirable.
  • NGS试剂盒开发经验
  • Experience in LIMS and data tracking system.
  • LIMS 和数据跟踪系统经验
  • Applications based on synthetic DNA, such as protein engineering.
  • 合成 DNA 的应用, 如蛋白质工程
  • Expert understanding in genetic and genomic sciences.
  • 对遗传学和基因组学的专业认解
  • Chemistry knowledge in DNA synthesis
  • 合成DNA的化学知识

 

Location:

  • Guangzhou
  • 广州
  • Travel to Twist's San Francisco facility is required to integrate with the San Francisco-based R&D team
  • 需要出差到旧金山与基于旧金山的研发部门进行整合

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