Totus Medicines, an innovative therapeutic drug discovery biotech, is just emerging from stealth. With a $40M Series A, Totus is poised to revolutionize drug discovery. For the first time, Totus is enabling genome-scale drug discovery to allow the identification of precision medicines for hard-to-drug targets. At its core, Totus is a chemical biology company. Totus’ novel proprietary platform allows screening at a rate more than 100,000 times faster than competitive technologies. Totus has pioneered the development of selective medicines for patients with genetically defined cancers and plans for its first program to enter Phase I by end of 2022. Totus also plans to expand their platform to create therapeutics targeted at neurodegeneration, infectious diseases, and others. We are searching for talented, passionate, high-energy candidates to join our growing team.

The Director of Clinical Sciences will provide strategic input and contribute to the execution of the development and medical affairs plans at Totus. This individual should desire leading or making strategic contributions while demonstrating strong scientific acumen and execution skills in a dynamic, collaborative environment, with opportunity for growth.

In this role you will:

  • Assists in writing clinical documents and amendments (clinical study protocols, Investigator’s brochure, ICF template) and in the preparation of clinical content for regulatory submissions/documents, in collaboration with other clinical team members
  • Support and contribute to requests for information from health authorities
  • Actively participates in clinical trial investigator feasibility, selection, training, and engagement to support clinical trial conduct and compliance, including site initiation and sponsor engagement visits
  • Participates in protocol training for study sites, study vendors and CRO staff
  • Partners with data management to develop data review plan and reviews patient level, and cumulative data per the data review plan, and coordinates with others for study level review; escalates questions to appropriate team members
  • Participates in interpretation and presentation of study results, including authoring of Clinical Study Reports
  • Supports the preparation, review, and submission of clinical publications and presentations
  • Leverage and manage vendors to support medical and scientific affairs deliverables
  • Lead or contribute to strategy and lead execution of advisory boards
  • In collaboration with CMO, develops and drives scientific communication strategy, ensuring alignment with company strategy and cross-functional partners
  • Provide updates relating to emerging data in the scientific literature regularly
  • Other duties as assigned

Requirements:

  • MD, PhD, or PharmD degree
  • 3+ years of drug development or medical or scientific affairs experience or equivalent clinical research experience at CRO or academic institution
  • Oncology experience is preferred
  • Ability to work independently
  • Strong understanding of GCP, clinical research process, including working knowledge of all functional areas of clinical trials and medical terminology
  • Ability to interact with all levels of staff to coordinate/execute study activities
  • Proficient at clinical data review including query generation and management
  • Demonstrated strong scientific acumen and desire to expand knowledge, expertise, and experience
  • Excellent written and verbal communication skills to express complex ideas to study personnel at research and clinical institutions
  • Experience working with external vendors for medical communication deliverables
  • Experience from developing/implementing medical communication strategy and tactics
  • Ability to travel as needed

What We Offer

  • A knowledgeable, high-achieving, experienced and fun team

  • A diverse work atmosphere

  • The chance to be part of a growing startup and the next success story

  • The opportunity to shape our company culture

  • Constant learning and dynamic challenges to help you grow and be the best version of yourself

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