Totus Medicines, an innovative therapeutic drug discovery biotech, is just emerging from stealth. With a $40M Series A, Totus is poised to revolutionize drug discovery. For the first time, Totus is enabling genome-scale drug discovery to allow the identification of precision medicines for hard-to-drug targets. At its core, Totus is a chemical biology company. Totus’ novel proprietary platform allows screening at a rate more than 100,000 times faster than competitive technologies. Totus has pioneered the development of selective medicines for patients with genetically defined cancers and plans for its first program to enter Phase I by end of 2022. Totus also plans to expand their platform to create therapeutics targeted at neurodegeneration, infectious diseases, and others. We are searching for talented, passionate, high-energy candidates to join our growing team.

We are seeking a lab-based chemist to contribute to Totus oncology programs.  This candidate will bring expertise in the design and synthesis of small molecules to drive Totus drug discovery programs.  You will be part of a dynamic organization and therefore you should be comfortable in a “building-mode” biotech setting where you will shape the company’s scientific strategy, culture, and mission. If this role excites you, reach out to Totus Medicines today to learn more.

In this role you will: 

  • Design and execute the synthesis of small molecules to support Totus oncology programs
  • Work collaboratively with the Totus laboratory team and external vendors in establishing and maintaining an efficient and safe chemistry laboratory
  • Foster a highly collaborative interdisciplinary scientific environment
  • Contribute to program success through assessment of data to drive efficient iterations and progression of chemical matter towards program goals
  • Work with internal scientists and external CROs to efficiently gather program driving data


  • 2+ years of industry experience in organic chemistry
  • Experience in modern chemistry techniques in compound synthesis, purification, and reaction monitoring.
  • Experience in the design and synthesis of covalent inhibitors is a plus
  • Experience in purchase and maintenance of instrumentation utilized in a synthetic chemistry laboratory is a plus
  • Ability to communicate effectively across scientific disciplines
  • Adept at searching literature and using modern tools to aid in design of synthetic schemes

What We Offer

  • A knowledgeable, high-achieving, experienced and fun team

  • A diverse work atmosphere

  • The chance to be part of a growing startup and the next success story

  • The opportunity to shape our company culture

  • Constant learning and dynamic challenges to help you grow and be the best version of yourself

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