Totus Medicines, an innovative therapeutic drug discovery biotech, is just emerging from stealth. With a $40M Series A, Totus is poised to revolutionize drug discovery. For the first time, Totus is enabling genome-scale drug discovery to allow the identification of precision medicines for hard-to-drug targets. At its core, Totus is a chemical biology company. Totus’ novel proprietary platform allows screening at a rate more than 100,000 times faster than competitive technologies. Totus has pioneered the development of selective medicines for patients with genetically defined cancers and plans for its first program to enter Phase I by end of 2022. Totus also plans to expand their platform to create therapeutics targeted at neurodegeneration, infectious diseases, and others. We are searching for talented, passionate, high-energy candidates to join our growing team.

About the Role:

We are seeking a Head of Platform Biology to develop and advance an industry first platform genome scale drug discovery. The position has the unique opportunity to create a vision and implement the strategy that will make a major impact in the drugging of hard-to-drug oncology targets. The Head of Platform Biology will lead both the development of a biology platform with a focus on developing target-based approaches to rapidly analyze target-small molecule biological effects. The successful candidate is a confident leader with extensive prior success in translational drug development, preferably in oncology. Experience with leading and working with computational biology and statistical biology teams to use multi-omics data to inform biology is preferred. Strong leadership skills including scientific and strategic management, team building, communication, and presentations to key stakeholders is required. You will lead the company’s biology platform and a team of highly talented scientists in addition to working together with the Platform Screening, Platform Chemistry, and Biophysics team to advance a series of new therapeutics targeting hard-to-drug oncology targets.



  • Define and execute the company’s discovery biology platform and strategy
  • Direct company’s efforts in hit validation
  • Direct company’s efforts in integration of multi-omic datasets to inform biology, including but not limited to: NGS, metabolomics, genomics, proteomics
  • Work closely with company’s SAB and other advisors to advance company’s biology platform
  • Build, lead and manage a high-performing group of talented scientists
  • Perform research and development in collaboration with other functions in projects pertaining to a range of potential indications
  • Communicate, as appropriate, efforts and progress to internal and external parties

Key Qualifications:

  • Ph.D. in biology or related discipline with 8-10 years of relevant post-Ph.D. experience in Biotech/Pharma with an excellent track record
  • Scientific leadership experience leading research teams working on multiple concurrent multidisciplinary projects
  • Experience in oncology and other therapeutic areas (e.g. immunology, oncology, metabolic disease, cardiology, neurology, or orphan diseases)
  • Experience with using multi-omics datasets
  • Successful track record of leading drug discovery programs especially with multiple targets and a class-based approach
  • Prior experience working with or leading collaborations with external academic, biotechnology, and contract research organizations

What We Offer

  • A knowledgeable, high-achieving, experienced and fun team

  • A diverse work atmosphere

  • The chance to be part of a growing startup and the next success story

  • The opportunity to shape our company culture

  • Constant learning and dynamic challenges to help you grow and be the best version of yourself

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