Tome Biosciences is the programmable gene insertion company. Using CRISPR, our technologies allow us to insert any genetic sequence of any size at any location into any genome. We are writing the final chapter in genomic medicines, delivering cures to patients through cell and genome engineering.
We are seeking a Senior Scientist to support the preclinical pharmacology team. The candidate will be responsible for leading, designing, and executing hands-on in-house rodent studies to determine pharmacodynamic properties and efficacy of test articles in preclinical studies supporting our platform and therapeutic programs.
Design, lead and execute animal studies to assess the pharmacological activity and efficacy of candidate drug test articles in preclinical studies to support development of novel therapies
Perform various molecular and biochemical assays on tissue samples from preclinical studies
Independent analysis and interpretation of data, careful documentation of experiments and presentation of results within the company
Work cross-functionally to advance Tome’s therapeutic programs and technology platform
PhD in biology, cell biology, molecular biology, or a related discipline with 2-5+ years of experience, BS or MS with 7+ years of experience in Biotech or pharmaceutical company
Experience planning and executing mouse studies is a must; experience with dosing of animals via IV route of administration; dosing of neonates is a plus
Experience with liver indications
Hands-on experience with CRISPR/Cas9 gene editing technology preferred
Familiar with running a variety of molecular and biochemical assays such as ddPCR, RT-qPCR, ELISA and luminescence-based assays
Generation of animal disease models as well as running efficacy studies is a plus
Ability to work independently as well as a part of a team
Document, interpret, and present own work
Work cross-functionally with excellent communication and organization skills