Tome Biosciences is the programmable gene insertion company. Using CRISPR, our technologies allow us to insert any genetic sequence of any size at any location into any genome. We are writing the final chapter in genomic medicines, delivering cures to patients through cell and genome engineering.

Scientist, In vivo Pharmacology

Watertown, MA

 

Tome Biosciences is developing a next-generation gene editing platform with the potential to transform gene therapy and cell engineering. The company is founded by leading CRISPR and gene editing pioneers from MIT and world-class investors using a novel platform developed at MIT. The early scientist team will play a leading role to translate the technology, define the early clinical pipeline, develop the scientific strategy for key pre-clinical experiments, and work at the cutting edge of gene editing therapeutic development.

We are seeking a Scientist (title flexible) to support the preclinical pharmacology team. The candidate will be responsible for leading, designing, and executing hands-on in-house rodent studies to determine pharmacodynamic properties and efficacy of test articles in preclinical studies supporting our platform and therapeutic programs.

Responsibilities:

  • Design, lead and execute animal studies to assess the pharmacological activity and efficacy of candidate drug test articles in preclinical studies to support development of novel therapies
  • Perform various molecular and biochemical assays on tissue samples from preclinical studies
  • Independent analysis and interpretation of data, careful documentation of experiments and presentation of results within the company
  • Work cross-functionally to advance Tome’s therapeutic programs and technology platform

Requirements:

  • PhD in biology, cell biology, molecular biology, or a related discipline with 0-3+ years of experience, BS or MS with 5+ years of experience in Biotech or pharmaceutical company
  • Experience planning and executing mouse studies is a must; experience with dosing of animals via IV route of administration
  • Hands-on experience with CRISPR/Cas9 gene editing technology
  • Experience with AAV and/or Adenovirus preferred
  • Familiar with running a variety of molecular and biochemical assays such as ddPCR, RT-qPCR, ELISA and luminescence-based assays
  • Generation of animal disease models as well as running efficacy studies is a plus
  • Ability to work independently as well as a part of a team
  • Document, interpret, and present own work
  • Work cross-functionally with excellent communication and organization skills

 

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