Passionate about precision medicine and advancing the healthcare industry?
Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time.
What You'll Do:
Develop a robust pipeline to functionally characterize and experimentally validate novel immunomodulatory pathways in human cancer.
Perform extensive phenotyping through multiple orthogonal methods (flow cytometry, IHC, single cell RNAseq) to understand the role of different immune pathways within the tumor microenvironment.
Establish novel co-culture systems to model the complex interactions between immune cells, antigen-presenting cells, stromal cells, and tumor cells.
Leverage gene editing technology to explore novel therapeutic avenues in immuno-oncology.
Work with cutting-edge immunology and biological modeling teams to facilitate the development of deep learning algorithms and functional assays.
PhD with 3+ years of postdoctoral experience
Demonstrated experience in immunophenotyping and functional characterization of immune genes and pathways, including high-dimensional flow cytometric analysis and sorting, expression profiling, and immunohistochemistry.
Substantial expertise in cell culture with specific experience with primary human T cells including T cell expansion, activation, in vitro killing, and co-culture assays.
Fundamental understanding of cancer pathophysiology
Supervisory experience either in an industry or academic setting
An ideal candidate has:
Experience preparing and analyzing cells from human tissue for profiling, sequencing, and functional assays
Previous experience with molecular cloning and methods for gene overexpression, knockdown, and editing (e.g., transient transfection, retroviral/lentiviral infection, siRNA, CRISPR-Cas9)
Rigorous attention to detail and ability to coordinate complex experimental procedures and workflows with a multidisciplinary team