Company Overview

Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.

Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.

This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.

The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts


Tango has an exciting new opportunity to join our growing IT team as an Associate Director of Business Systems. In this role you will plan, implement, manage, administer, and support core business application software for corporate enterprise needs; in addition, you will define the strategy and architecture for enterprise data storage, standards, and technologies. This includes all global applications across the spectrum of business development for the Discovery, Research and Development, General & Administration, Technical Operations, and eventually, Commercial business units.

Your role:

  • You will maintain the current Information Architecture and implement accompanying infrastructure to support the digital strategy
  • Oversee master data management systems and tools, supporting broader data governance efforts to drive data quality
  • Manage, plan, and maintain significant budget cycles for technology projects, as well as ongoing licenses and support/maintenance contracts for the application portfolio
  • Collaborate with IT management and liaisons in the planning and implementation of corporate production applications, systems, and core infrastructure
  • Monitor, maintain, administer, and support enterprise application software to meet or exceed service level agreements
  • Create and maintain documentation for application configurations, services, network mapping, processes, security, and compliance configurations
  • Participate and help develop, implement, and maintain policies, procedures, and associated training plans for the administration and usage of core enterprise applications and systems
  • Participate and assist in the planning of corporate disaster recovery exercises and drills
  • Oversee installation, configuration, maintenance, and troubleshooting of application software, infrastructure, and peripheral devices
  • Analyze and resolve problems with all Enterprise Applications
  • Provide for the support and troubleshooting of corporate enterprise applications and systems as required
  • Configure and deploy application software and systems to ensure smooth and reliable operation to fulfill business objectives and processes
  • Monitor systems performance and troubleshoot problem areas as required
  • Provide technical support, primarily for GxP-validated computer systems
  • Ensure systems are validated in accordance with regulatory requirements, such as 21 CFR Part 11
  • Maintain good working relationships with selected business units and vendors
  • Provide IT-specific guidance to departments for outsourcing needs
  • Assume IT lead for installation, validation, troubleshooting, and management of hardware and software for all R&D, G&A, and Discovery systems
  • Responsible for application user and group administration
  • Additional duties and responsibilities as required

What you bring:

  • Bachelor’s degree with 10+ years of relevant work experience supporting enterprise systems, preferably in a biotech/pharma organization. Equivalent work experience will be considered
  • Experience with Microsoft Office 365, R&D Systems, and enterprise document management systems (Egnyte, Veeva, etc.)
  • Demonstrated experience in solution design and enterprise architecture, with focus on scalability and automation
  • Must be knowledgeable of server class hardware and network infrastructure best practices
  • Ability to analyze financial and technical data to support the development and implementation of technological solutions for distinct business units
  • Ability to manage projects simultaneously, manage conflicting priorities, and be flexible when priorities change
  • Ability to manage, mentor, and direct the personal development of staff
  • Demonstrate excellent leadership and communication skills
  • Demonstrate strong organizational skills, including the ability to prioritize
  • Experience working in a pharma/biotech environment on FDA/GxP-validated systems, including 21 CFR Part 11 and applicable regulations, guidance, and compliance requirements related to computerized systems
  • Experience with ensuring IT systems and processes comply with other regulations such as SOX, GDPR, HIPAA, and other regulations as applicable




We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.



Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
When autocomplete results are available use up and down arrows to review
+ Add another education

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Tango Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Enter the verification code sent to to confirm you are not a robot, then submit your application.

This application was flagged as potential bot traffic. To resubmit your application, turn off any VPNs, clear the browser's cache and cookies, or try another browser. If you still can't submit it, contact our support team through the help center.