Spyre Therapeutics

At Spyre, we are driven by our mission to develop potentially best-in-class therapeutics for people living with IBD. We are a collaborative interdisciplinary team of innovators seeking motivated individuals who are looking to make a positive impact and join an exciting new organization.

As we continue to grow, new positions will be posted. Check back regularly if you don’t see anything that matches your current interests.


Spyre offers an opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture of our young company, wear multiple hats, and learn quickly. We are committed to growing you professionally and providing access to resources to further your development.

We offer a comprehensive benefits package for all new employees:

  • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits.
  • Unlimited PTO and two, one-week company-wide shutdowns each year
  • 100% remote with frequent all team, in-person meetings to build relationships and problem solve

Current Job Openings

Research & Development

Non-Clinical Development