About SpringWorks Therapeutics

SpringWorks Therapeutics is a clinical-stage biopharmaceutical company applying a precision medicine approach to acquiring, developing, and commercializing life-changing medicines for underserved patient populations suffering from devastating rare diseases and cancer. SpringWorks has a differentiated portfolio of small molecule targeted oncology product candidates and is advancing two potentially registrational clinical trials in rare tumor types, as well as several other programs addressing highly prevalent, genetically defined cancers. SpringWorks’ strategic approach and operational excellence in clinical development have enabled it to rapidly advance its two lead product candidates into late-stage clinical trials while simultaneously entering into multiple shared-value partnerships with industry leaders to expand its portfolio.

The Principal Biostatistician is responsible for providing statistical expertise for company products within one or more therapeutic areas.   As a lead statistician, the Principal Biostatistician will lead study designs, protocol development, analysis plans, file/report specifications, and review study setup activities, including but not limited to randomization, CRFs, and data edits. They will perform design studies, identify appropriate statistical methods, conduct analyses, interpret statistical results, and prepare clinical study reports, including integrated summaries for submissions as appropriate. As an active member of the Biometrics group, they will also aid in process improvement initiatives, stay abreast of current statistical methodology, and provide mentorship to new/junior biostatisticians.

Essential Duties and Responsibilities:

  • Provide statistical expertise to support clinical development objectives and strategy, representing Biostatistics in cross-functional teams.  
  • Define statistical methodology, analyze data and reports results, and contribute to the strategic planning and execution of the clinical development plan for the assigned project; train and supervise contract statisticians and ensure their deliverables' quality.
  • Serve as a content author or peer reviewer for material authored or coauthored by other statisticians and other clinical research personnel and acts as an internal consultant on broad statistical issues that impact the pharmaceutical/biotechnology industry.
  • Provide written and verbal responses to statistical issues as part of regulatory, legal, corporate processes; may represent Biostatistics in critical meetings as assigned.
  • Participate in approved process improvement initiatives; mentor new/junior biostatisticians; keep up-to-date on statistical methodology and software/tools. Conduct modeling and simulations as needed.
  • Promote innovative statistical methodology approaches by identifying, adapting, and developing optimal statistical research methodologies and techniques.
  • Contribute internally and externally to the company's development and visibility and the Biometrics department through their expertise and customer orientation.
  • Develop strong collaboration and communication with cross-functional teams and Biometrics management.

Education and Experience:


  • PhD (preferred) or master’s degree in Statistics, Biostatistics or related discipline.


  • 15+ years (PhD 7-8 years or Masters + 10-11 years) of related experience in statistical or biostatistical analysis supporting drug development, clinical trial operations, and worldwide regulatory submissions within the pharma/biotech industry. Experience within oncology is preferred. 
  • Demonstrable knowledge of global regulatory requirements. Extensive experience with written and verbal communications to regulatory agencies is a must. 
  • Extensive statistical modeling experience including, but not limited to complex statistical methods and models, principles of statistical inference, hypothesis testing, deriving estimates, parametric and non-parametric models, sample size calculations for comparing multiple arms, and phase I-IV clinical trial data analysis. Bayesian and adaptive design experience is preferred.
  • Ability to translate and implement a broad understanding of statistical principles for all phases of drug development. Ability to develop innovative/creative statistical/technical solutions to complex problems.



  • Proficient with SAS, R, Sample size calculation software (e.g., East, PASS, NQuery). Other analytical software is a plus.
  • Demonstrable experience using CDISC data standards, specifically ADaM. SDTM, CDASH, and other CDISC standards are a plus.
  • Ability to write statistical code and documentation


  • A strong team player with the ability to collaborate in cross-functional teams.
  • Able to work cooperatively and independently in a fast-paced, matrixed environment
  • Demonstrates ability to translate & present complex information to others effectively.
  • Ability to influence without direct authority
  • A detail-oriented, pro-active, enthusiastic, and goal-oriented personality  


  • Excellent communication and interpersonal skills to effectively interface with others
  • Must communicate, develop, and maintain strong relationships with regulatory agencies (e.g., FDA, PMDA, etc.), internal stakeholders, and external stakeholders (e.g., CROs). 
  • Practical technical writing skills, especially the ability to clearly and succinctly author regulatory documents.


Ability to travel domestically for meetings as necessary.

Are you a SpringWorker?

How much do you care?
How well do you partner with others?
How fast do you move?
Are you a problem solver?
Are you comfortable challenging convention?

At SpringWorks Therapeutics, we ignite the power of promising science to unleash new possibilities for patients.   We work hard, we care even harder and we’re in it together.  We are looking for ambitious, smart, and hardworking colleagues to join our growing team.                                  

SpringWorks Therapeutics is an Equal Employment Opportunity employer. All qualified applicants/employees will receive consideration for employment without regard to that individual’s age, race, color, religion or creed, national origin or ancestry, sex (including pregnancy), sexual orientation, gender, gender identity, physical or mental disability, veteran status, genetic information, ethnicity, citizenship, or any other characteristic protected by law.

GDPR Statement:  When you apply to a job on this site, the personal data contained in your application will be collected by SpringWorks Therapeutics (“Controller”), which is located at 100 Washington Blvd, Stamford CT 6902 and can be contacted by emailing hr@springworkstx.com . Your personal data will be processed for the purposes of managing Controller’s recruitment related activities, which include setting up and conducting interviews and tests for applicants, evaluating and assessing the results thereto, and as is otherwise needed in the recruitment and hiring processes. Such processing is legally permissible under Art. 6(1)(f) of Regulation (EU) 2016/679 (General Data Protection Regulation) as necessary for the purposes of the legitimate interests pursued by the Controller, which are the solicitation, evaluation, and selection of applicants for employment.

Your personal data will be shared with Greenhouse Software, Inc., a cloud services provider located in the United States of America and engaged by Controller to help manage its recruitment and hiring process on Controller’s behalf. Accordingly, if you are located outside of the United States, your personal data will be transferred to the United States once you submit it through this site. Because the European Union Commission has determined that United States data privacy laws do not ensure an adequate level of protection for personal data collected from EU data subjects, the transfer will be subject to appropriate additional safeguards under the standard contractual clauses. You can obtain a copy of the standard contractual clauses by contacting us at hr@springworkstx.com.

Your personal data will be retained by Controller for as long as Controller determines it is necessary to evaluate your application for employment.  Under the GDPR, you have the right to request access to your personal data, to request that your personal data be rectified or erased, and to request that processing of your personal data be restricted. You also have to right to data portability. In addition, you may lodge a complaint with an EU supervisory authority.

Apply for this Job

* Required


Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in SpringWorks Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.