tl;dr
Spring is accelerating the discovery of therapies for aging and its related diseases. A tight integration of biology and machine learning is at our core, and we're building a rare team of scientists and computational folks that work together closely, fighting disease.
 
We're hiring an immunologist to drive Spring's efforts to battle the aging immune system, using our platform to find therapies for immunosenescence and its associated diseases.

Impact
Aging is the single greatest risk factor for the most detrimental diseases on Earth — cardiovascular disease, neurodegenerative disease, pulmonary disease, cancer, muscle wasting, and more — and drugs that slow the biological damage accumulated while aging have the potential to reduce the incidences of these diseases, possibly simultaneously. We believe that in the not-too-distant future, the discovery of therapies for aging will provide some of the most effective tools in history for reducing our burden of disease and extending our healthy lifespan.

Our mission is to dramatically accelerate the realization of that future. And we’re bringing a new set of machine learning tools to bear on this challenge.

Yes, you belong
We are building a cross-functional team. We don't expect you to have a background in machine learning, just as we don't expect our computational folks to be expert biologists. We do expect our teams to work respectfully and closely, learning together every day.

We value building a diverse, inclusive environment and welcome all applicants regardless of gender, sexual orientation, ethnicity, race, education, age, or other personal characteristics.

About you
  • Demonstrated experience in the discovery and preclinical development of immune therapeutics
  • Demonstrated expertise in the field of immunology, cell biology, and/or genetics
  • Broad experience in assessing innate (myeloid) and acquired (T cell) immune cell function, differentiation, immune cell trafficking, and response to pathogens / vaccine
  • Experience designing and applying syngeneic and humanized immune response models to evaluate novel immunomodulating candidates
  • Technical expertise in flow cytometry, cell sorting, confocal microscopy, and gating immune cell populations
  • Prior experience working with or leading collaborations with external academic, biotechnology, and contract research organizations
  • Experience in mentoring and/or leading Ph.D. level and non-Ph.D. level scientists
  • Ability to organize and communicate complex data sets in a clear and concise manner to key stakeholders from diverse backgrounds
  • Ph.D. with 6+ years of relevant post-Ph.D. experience in Biotech/Pharma
  • Passion for using broad, high content information to measure cell function rather than traditional markers
  • You do anything necessary to solve the problem at hand
  • You love learning and teaching others in a cross-functional team (we're biologists, computational folks, and more).
  • You're most motivated when working on a problem of important consequence, no matter what's necessary to do so.

Key Responsibilities:

  • Drive discovery and development of new therapeutics for improving elderly vaccine response
  • Invent and evolve a whole new way to profile the immune system using high content imaging 
  • Lead and participate in collaborations with internal and external collaborators to pursue the most promising drug candidates through clinical trials
  • Build a world-class immunology team
  • Write and contribute to intellectual property, study reports, regulatory filings, and scientific presentations
  • Present at group, company, and external meetings/conferences
  • Contribute to a dynamic and exciting culture that embraces teamwork and innovation

Benefits
  • Competitive salary and equity in a growing, well-funded startup
  • Excellent medical, dental, and vision coverage
  • Generous vacation policy
  • Healthy feedback-focused environment — leadership will have high expectations, regularly share constructive feedback, expect you to grow, and welcome receiving feedback from you

A unique moment
We have deep support from some of the best investors in the world: General Catalyst, First Round, Felicis, Laura Deming's Longevity Fund, pharma/biotech angels, and many more. Our advisors are world leaders in aging research, senior execs at pharma, and top tech entrepreneurs.

And at the same time, we're just getting started. You're joining a team that has the funding needed to be ambitious while still early enough to help define our culture, choices, and success. Our expectations of you — and of ourselves — are high.

To fighting disease, together!

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