ShapeTX® is pioneering the field of programmable RNA medicines to repair the genetic causes of diseases. By merging innovations in AI and RNA technology to generate and analyze hundreds of billions of therapeutic possibilities, ShapeTX is developing breakthroughs in RNA editing, next-generation AAVs, and disruptive gene therapy manufacturing. The ShapeTX platform enables pharma innovators to design treatments across a wide range of diseases, including rare genetic disorders as well as debilitating conditions, such as Alzheimer’s, Parkinson’s, and many more. You can find us at and on LinkedIn and Twitter.

At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases.

Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Boston, Massachusetts.

Position Overview

ShapeTX is looking for a highly motivated Scientist I / Scientist II to join our Research Technologies Team to further develop our RNAfixTM technology. In this role, you will be responsible for designing and optimizing assays for screening of our RNAfix payloads. Your experience in cell and molecular biology and attention to detail will be critical to producing highly robust and reproducible assays to transition our workflows to automation. In close collaboration with an automation engineer, you will help to build an end-to-end automated workflow that will support multiple ongoing projects and be instrumental in identifying lead candidates for advancement into pre-clinical studies. Thriving in a fast-paced startup environment, characterized by autonomy, initiative, and a shared passion for research, along with excellent communication and collaboration is essential to excel in this role. Additionally, maintaining a can-do attitude even in the face of technical challenges will be a valuable asset to our team's success. 

You will join our satellite site in Boston. Meet some of the team members here.

What You’ll Do:  

  • Assay Optimization: Work collaboratively with our Automation Engineer to optimize cell and molecular biology assays for automation, ensuring accuracy and reliability. 
  • Workflow Integration: Collaborate closely with the Automation Engineer to integrate optimized assays into automated workflows, streamlining laboratory processes.
  • Data Analysis: Analyze and interpret data generated from automated experiments, identifying areas for improvement and refinement, and make data-driven decisions.
  • Problem Solving: the ability to quickly diagnose problems, identify solutions, and maintain a can-do attitude.
  • Documentation: Maintain comprehensive documentation of assay protocols, automation processes, and troubleshooting procedures.
  • Collaborative Research: Collaborate with cross-functional teams of scientists to contribute to cutting-edge research projects.
  • Continuous Improvement: Stay updated on the latest advancements in cell and molecular biology and automation technologies, recommending and implementing improvements to assays and processes.
  • Quality Assurance: Implement quality control measures to ensure the accuracy and reliability of automated assays. 

What You Bring: 

  • Cell and Molecular Biology Expertise: A strong background in cell and molecular biology, with hands-on experience in assay development, cell culture, molecular techniques, and NGS.  
  • Automation: Experience and familiarity with automation systems and the ability to collaborate effectively with an Automation Engineer to integrate assays into automated workflows. 
  • Collaboration: Proven ability to work collaboratively in cross-functional teams, particularly with Automation Engineers, to optimize and automate laboratory processes.
  • Detail-Oriented: Meticulous attention to detail and a commitment to producing high-quality, reproducible results.
  • Analytical Skills: Proficiency in data analysis and interpretation, with the ability to troubleshoot and refine assays for improved performance.
  • Problem-Solving: Strong problem-solving skills and the ability to adapt assays to meet specific research needs.
  • Communication Skills: Excellent communication skills, both written and verbal, to document experimental procedures and collaborate effectively with team members.
  • Innovation: A passion for innovation and a desire to push the boundaries of scientific research through automation.
  • Education & Experience: A PhD in Biology or a related discipline. Non-PhD candidates with 5-10+ years of at-the-bench experience and demonstrated success within the biotech industry will be considered. 

ShapeTX offers a robust benefits package, including but not limited to: Medical, Dental and Vision coverage for employees and their eligible dependents. We provide eligible employees with 12 paid Holidays plus a one-week winter break at year end. We are proud to offer a competitive paid parental leave benefit, an annual employee stipend for employees to use however they choose, a Flex Paid Time Off program (allowing flexible PTO for vacation, sick leave, and other purposes) and Company paid Long Term Disability. Employees are eligible to enroll in our Company’s voluntary 401k plan, voluntary Life/AD&D and Voluntary FSA’s.

The salary range for the Scientist/Scientist II role is $96,000-$144,000. The hired applicant's placement within the range is based on qualifications and professional experience. Additional compensation may include annual target bonus and/or sign-on bonus, equity grant and relocation bonus.

We aspire to Shape Life! not only through our science, but also through our commitment to foster an inclusive environment that supports diverse perspectives and experiences.

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