Shape Therapeutics is a biotechnology company developing breakthrough gene therapy technologies to treat the world’s most challenging diseases. ShapeTX gene therapy platform comprises RNAskip™, RNAfix™, and RNAswap™ payload technologies, next-generation tissue-specific AAVid™ delivery technology, and SquareBio, a solution to scalable gene therapy manufacturing based on industrialization of human stable cell lines. At the core of these technologies reside ShapeTX AI analytic platform, where data drives decisions in building technology today to enable gene therapies of tomorrow. ShapeTX is committed to data-driven scientific advancement, passionate people, and a mission of providing life-long cures to patients. Shape Life!

At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases.

Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.


ShapeTX is looking for a molecular biologist with strong synthetic biology and library cloning experience to join the Platform Technologies team as Associate/Senior Associate Scientist, AAV Engineering. In this position, the successful candidate will join the AAV Engineering team and develop workflows that allow ShapeTX to discover powerful new gene therapy vectors through massively diverse in vivo screening of AAV capsid variants. The ideal candidate will have significant experience performing a variety of cloning techniques, including library assemblies. Candidates should have demonstrated experience in troubleshooting and improving cloning methods. To enable these key experimental workflows, you will help maintain lab organization through a diligent and detail oriented working style. In addition, scientific creativity, a collaborative spirit, and a desire to work in a fast-paced startup environment are essential.

Title and compensation will be commensurate with level of experience.

Roles and Responsibilities may include:

  • Contribute to novel AAV capsid discovery through construction of AAV libraries
  • Optimize and develop improved molecular biology methods
  • Apply libraries to in vivo and in vitro models to evaluate capsid performance (tropism, biodistribution, production, etc.)
  • Design and perform in vivo and in vitro validation experiments on lead designs
  • Work with disease biology leads to design and execute a delivery strategy for disease programs
  • Develop and deploy cutting-edge library engineering technologies
  • Keep organized and detailed records using an electronic laboratory notebook

Qualifications:

  • Bachelor's or Master's Degree in Molecular Biology, Virology, Genomics or a related discipline
  • 3+ years of laboratory experience in an academic or industry setting
  • Ability to work both independently and collaboratively in a team-science environment
  • Ability to think outside the box and tackle challenges with a problem-solving, can-do attitude

Preferred Skills and Experience:

  • Broad molecular biology expertise
  • Experience with a variety of cloning techniques (restriction enzyme cloning, Gibson Assembly, Golden Gate Assembly, etc.)
  • Experience with library assembly (e.g. CRISPR, MPRA, siRNA, Phage, or other similar libraries)
  • Experience optimizing library cloning and NGS validation
  • Possession of a high degree of energy, flexibility, motivation and a strong work ethic
  • Ability to work independently and collaboratively in a team-science environment
  • Ability to think outside the box and tackle challenges with a problem-solving attitude
  • Excellent written and verbal communication skills

We aspire to Shape Life! not only through our science, but also through our commitment to foster an inclusive environment that supports diverse perspectives and experiences.

Apply for this Job

* Required

resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)


Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Shape Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.


Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.