Shape Therapeutics is a biotechnology company developing breakthrough gene therapy technologies to treat the world’s most challenging diseases. ShapeTX gene therapy platform comprises RNAskip™, RNAfix™, and RNAswap™ payload technologies, next-generation tissue-specific AAVid™ delivery technology, and SquareBio, a solution to scalable gene therapy manufacturing based on industrialization of human stable cell lines. At the core of these technologies reside ShapeTX AI analytic platform, where data drives decisions in building technology today to enable gene therapies of tomorrow. ShapeTX is committed to data-driven scientific advancement, passionate people, and a mission of providing life-long cures to patients. Shape Life!

At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases.

Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.


ShapeTX is looking for a highly motivated individual to join the Pipeline Research team as an Associate Scientist / Senior Associate Scientist / Scientist, Cell biology. In this role, the successful candidate will design and execute in vitro cell-based assays to evaluate ShapeTX’s novel RNAfixTM and RNAskipTM technology platforms. The ideal candidate will have broad cell biology or neurobiology experience, a collaborative spirit, and a desire to work in a fast-paced startup environment.

Roles and Responsibilities

  • Develop and characterize in vitro models of disease-specific pathologies
  • Quantitate disease pathology with protein analysis, including flow cytometry and high content imaging
  • Screen for lead candidate efficacy and therapeutic window in these in vitro disease-specific models
  • Collaborate cross functionally with the cell line engineering, platform technologies, vector optimization, and in vivo pharmacology groups to support lead candidate selection
  • Write protocols and study reports
  • Analyze and communicate results in written and oral presentations
  • Maintain a detailed and up-to-date electronic laboratory notebook

Requirements:

Preferred Qualifications:

  • Title will be commensurate with experience:
    • Associate Scientist: BS + 4 years or MS + 1 year of experience
    • Senior Associate Scientist: BS + 6 years or MS + 3 years of experience
    • Scientist: PhD (0-3 years post-doc experience) or BS (+10 years of experience) or MS (+5 years of experience) in cell biology, neurobiology, or a related discipline in a laboratory setting
  • Demonstrated scientific rigor through peer-reviewed publications or documented contributions to drug discovery project teams
  • Ability to work both independently and collaboratively in a team-science environment
  • Ability to think outside the box and tackle challenges with a problem-solving, can-do attitude

Skills and Experience:

  • Extensive cell culture experience, including iPSC culture and differentiation strongly preferred
  • Experience with molecular biology techniques (DNA/RNA purification, Sanger sequencing, qPCR, ddPCR)
  • Experience with protein analysis techniques (ELISA, Western blotting, Flow cytometry, IHC, high content imaging)
  • Ability to multitask and support multiple projects simultaneously
  • A collaborative, team player, and good lab citizen
  • Takes initiative with demonstrated ability to troubleshoot and think analytically
  • Exquisite attention to detail and organization
  • Effective and proactive communication

Shape Life!

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