Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies. 

At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.

The Process and Product Development team at ShapeTX is seeking an experienced, highly motivated individual for the role of Scientist / Senior Scientist, Upstream Development. In this position, you will develop and implement suspension mammalian cell culture procedures for expression of ShapeTx’s novel gene therapy technology platform. Candidates should have expertise in early phase upstream development with specific experience in developing seed train cell culture platforms for monoclonal cell lines. The ideal candidate will have a strong problem-solving attitude, ability to effectively communicate results, ideas, and concepts to cross functional teams, and intellectual motivation to understand and optimize upstream processes for a high expression system.

Roles and Responsibilities:

  • The candidate will work as a member of the P&PD team to lead and perform upstream development to create platform processes for the expansion of stable cell lines from vial thaw to bioreactor inoculation to support rAAV viral vector production.
  • The main responsibility of this position is to perform of cell culture optimization, media development, other screening activities for optimum cell culture conditions to support high cell density, viability and superior rAAV product quality.
  • She/he will be also responsible for working with the P&PD team to support all aspects of process development from small scale screening activities to lab scale material generation for downstream and analytical development.
  • Participate in ongoing upstream technology development initiatives, as well as generating new ideas and proposals for future projects
  • As part of a growing development team, the candidate may be required to perform activities across the team in addition to upstream experiments (i.e., cell line, bioreactor, and/or analytical development).
  • Some weekend work may be necessary to maintain cell lines, perform critical monitoring, etc.

Qualifications:

  • PhD in biochemistry, molecular biology, cell biology, bioengineering or related field with 3-5 years of industry experience in cell line development. Excellent non-PhD candidates will also be considered.
  • Demonstrated scientific rigor through peer-reviewed publications in top tier journals

Skills and Experience:

  • Proficiency with standard mammalian cell culture techniques involved in creating viral or biological therapeutics
  • Working knowledge of media development, cell culture optimization, and/or cell line engineering for optimum growth, yield and/or product quality
  • Demonstrated experience in upstream process development
  • Experience with high throughput tools, experimental design and analysis as pertains to upstream development
  • Strong background in aseptic techniques
  • Ability to collaborate and work effectively on cross functional teams, and rapidly adapt technologies and processes to meet project needs
  • Strong technical writing skills to author reports and appropriate regulatory filing sections
  • Critical thinking and clear verbal communication skills
  • Familiarity with GMP requirements and experience with regulatory documents (IND, BLA, etc.)
  • Familiarity and experience with current viral vector manufacturing techniques a plus

 

Shape Life! 

Apply for this Job

* Required
  
Attach Dropbox Google Drive Paste
  
Attach Dropbox Google Drive Paste

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Shape Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.