Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies.
At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.
The Process and Product Development (P&PD) group at Shape Therapeutics is seeking a cell-culture and molecular-biology expert for the role of Associate Scientist (AS). In this role, the successful candidate will perform a variety of laboratory experiments that support the development and implementation of ShapeTX’s proprietary rAAV production platform. Primary responsibilities will include development and maintenance of stable cell lines, generation of knock-out and knock-in cell lines using CRISPR (or similar) technology, and screening of single-cell clones. The ideal candidate will be creative in his/her approach to scientific problems and will possess a strong work ethic and team-oriented mentality. This is an excellent opportunity to join a rapidly growing biotechnology company and to have a tangible impact on the development of novel platforms and products that treat serious human disease.
[Note: all candidates with relevant experience are encouraged to apply. Job title and salary will be commensurate with experience.]
Roles and Responsibilities:
- Generate cell lines via stable transfection (e.g., transposase, linear integration, etc.)
- Isolate single-cell clones via limiting dilution and/or single-cell seeding
- Screen large numbers of clones for desired production properties
- Execute knock-out and knock-in genome-editing experiments using a wide variety of techniques (e.g., CRISPR, ZFNs, TALENs, etc.)
- Keep appraised of current literature, bringing new ideas to support cell-line-engineering efforts
- Efficiently organize time and resources to meet deadlines
- Maintain a detailed electronic laboratory notebook
- Bachelor’s Degree in Molecular Biology, Cellular Biology, or Biochemistry (or a related discipline) with 4+ years of experience in an industry setting, OR
- Master’s Degree in Molecular Biology, Cellular Biology, or Biochemistry (or a related discipline) with 1+ years of experience in an industry setting
Skills and Experience:
- Experience with mammalian cell-culture techniques
- Experience with generation of stable cells and single-cell cloning
- Familiarity with CRISPR-Cas9 genome editing, or similar technology
- Previous work with AAV and gene therapy a plus (but not required)
- Passion for innovation and developing creative solutions to scientific problems
- Ability to troubleshoot and think analytically
- Strong work ethic and a team player
- Ability to effectively communicate via email, interpersonally, and in presentation