Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies.
At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.
The Technology Development group at Shape Therapeutics is looking for a highly motivated Research Associate/Senior Research Associate (RA/SRA) with demonstrated experience in molecular and cell biology laboratory techniques. In this role, the successful candidate will perform a variety of laboratory experiments that support the discovery and characterization of novel RNA-targeted gene therapy payloads for translational applications. The ideal candidate will have a diligent and detail-oriented working style. The candidate will be expected to keep detailed experimental records, and precisely communicate experimental results to their supervisor and other team members. This is an excellent opportunity to join a rapidly growing biotechnology startup, with a large opportunity to contribute to the development of new technologies for treating serious human diseases.
Relevant Skills and Experience
- Standard cloning, Gibson Assembly, and Golden Gate Assembly
- PCR/qPCR/RT-PCR/ddPCR principles and analyses, DNA/RNA isolation
- Mammalian cell culture techniques and in-vitro assays
- Immunoblotting, immunofluorescence, ELISA, and flow cytometry
- Troubleshooting and analytical thinking
- Effective communication via email, in-person, and in presentations
- Strong work ethic and a team player
Roles and Responsibilities
- Independently clone novel plasmid and other genetic constructs
- Perform Sanger sequencing and analyze results
- Assist with mammalian cell line generation and maintenance
- Conduct cell transfection/transduction experiments
- Isolate RNA and generate cDNA
- Conduct qPCR and ddPCR
- Maintain a detailed electronic laboratory notebook
- Efficiently organize time and resources to meet deadlines
- Bachelor’s degree in Molecular Biology, Cell Biology, Bioengineering, or a related discipline
- 2+ years of post-degree experience in an academic lab or industry setting