Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies.
At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.
ShapeTX is looking for a Scientist with a strong background in molecular biology, gene editing and transgene delivery to join the Technology Development team at our Seattle, WA headquarters. In this position, the successful candidate will design and execute research projects related to ADAR-based RNA editing, and in particular the discovery and optimization of novel payload approaches and designs that advance efficiency and specificity of the technology across various targets and tissue types. The ideal candidate will have broad experience in molecular, cellular and synthetic biology, and ideally a deep understanding of RNA editing technologies. This position will directly contribute to the expansion of ShapeTX’s core technology platforms, with applications across multiple diseases with huge unmet medical need. Scientific creativity, collaboration and a desire to work in a fast-paced research environment are essential.
Roles and Responsibilities
- Develop and execute screening approaches to discover and engineer guide RNAs for targeted ADAR editing
- Partner with the disease biology and delivery sciences teams to optimize lead designs and screening methods
- Collaborate with the data sciences team to harmonize experimental and computational workflows
- Summarize data and results in written reports and in formal presentations to the Research team and the senior leadership team
- Maintain a detailed electronic laboratory notebook
- PhD in molecular biology or a related discipline, with 2+ years of post-degree experience in an academic or industry laboratory setting a plus.
- BS or MS in molecular biology or a related discipline with 10+ years of experience in an industry laboratory setting.
Skills and Experience:
- Highly skilled in molecular biology and construct engineering
- Highly skilled in gene editing
- Highly skilled in mammalian cell culture
- Experience with next-generation sequencing methods
- Ability to troubleshoot, think analytically, and provide creative and novel solutions
- Strong work ethic and a collaborative, team player
- Strong attention to detail
- Ability to mentor and train junior members of the team
- Effective communication, both written and orally