Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies.
At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.
ShapeTx is looking for a dedicated and innovative problem-solver to join the Translational Sciences team as Senior Scientist, Translational Neurology. In this role, the successful candidate will design and implement biomarker discovery strategies to support development of novel therapeutics in neurodevelopmental and neurodegenerative diseases. The ideal candidate will have broad neurobiology experience, a collaborative spirit and a desire to work in a fast-paced startup environment.
Roles and Responsibilities
- Utilize creative approaches to identify biomarkers in neurologic disorders using mouse models, human patient samples, and iPSC or other model systems
- Design and execute experiments to inform mechanism of action, patient selection and drug combination hypotheses
- Collaborate with bioinformatics colleagues to generate high dimensional datasets (RNASeq, WGS, epigenetic, metabolomic, proteomic) to inform biomarker strategies applicable to human clinical studies
- As a member of a cross-functional project team, work closely with preclinical research, toxicology, PK, and clinical development team members to develop an integrated biomarker analysis plan for early phase clinical studies
- Manage a small team of direct reports as well as studies performed by external partners
- PhD in neurobiology, cell biology, or a related discipline with 4+ years post-doctoral experience. Prior industry experience a plus
- Demonstrated scientific rigor through peer-reviewed publications or documented contributions to drug discovery project teams
- Ability to work both independently and collaboratively in a team-science environment
- Ability to think outside the box and tackle challenges with a problem-solving, can-do attitude
Skills and Experience:
- Experience culturing, maintaining, and differentiating neuronal cell lines, primary cells, and/or iPSC lines into neural cell types. Familiarity with gene therapy delivery techniques (AAV transduction) a plus
- Genetic and epigenetics techniques including DNA/RNA isolation, qPCR and ddPCR, and DNA methylation analysis
- Protein analysis techniques including ELISA, MSD, western blot
- Cell or tissue-based methods including flow cytometry, ISH, IHC/IF
- Experience with imaging and electrophysiological techniques, including wearable devices or other cutting-edge technologies, is highly desired