Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies. 

At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.

ShapeTX is looking for a highly motivated individual with a strong passion for learning to join the growing Research team as Scientist, Neurobiology. In this role, the successful candidate will design and execute in vitro cell-based assays to evaluate ShapeTX’s novel RNAfixTM and RNAskipTM technology platforms. An ideal candidate will have broad neurobiology experience, a collaborative spirit and a desire to work in a fast-paced startup environment.

Roles and Responsibilities

  • Independently plan and execute rigorous and well-controlled experiments
  • Analyze and communicate results in written and oral presentations
  • Delve into the literature to inform assay development and project strategies
  • Develop assays and write protocols
  • Identify and model disease specific pathologies in vitro
  • Screen for lead candidate efficacy in neuronal cell lines, primary neural cells, iPSC-derived neural cell types
  • Test lead candidate dosage and kinetics in iPSC-derived neural cell types
  • Perform a broad range of cell biology techniques (e.g. DNA isolation, RNA isolation, cDNA generation, qPCR, ddPCR, ELISA, immunoblotting, immunofluorescence, flow cytometry etc.)
  • Maintain a detailed and up-to-date electronic laboratory notebook

Requirements:

Preferred Qualifications:

  • PhD in neurobiology, cell biology, or a related discipline
  • Exceptional non-PhD candidates with a demonstrated track record of drug discovery expertise in an industry setting are also encouraged to apply
  • Demonstrated scientific rigor through peer-reviewed publications and/or documented contributions to drug discovery project teams
  • Ability to think outside the box and tackle challenges with a problem-solving, can-do attitude

Skills and Experience:

  • Experience culturing, maintaining, and differentiating neuronal cell lines, primary cells, and/or iPSC lines into neural cell types 
  • DNA/RNA purification
  • qPCR/ddPCR technique and analysis
  • ELISA/WB technique and analysis
  • Flow cytometry - surface and intracellular staining
  • Ability to troubleshoot and think analytically
  • Strong work ethic
  • A collaborative, team player and good lab citizen
  • Exquisite attention to detail
  • Effective and proactive communication
  • Ability to multitask and support multiple projects simultaneously
  • Ability to work both independently and collaboratively in a team-science environment

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