Shape Therapeutics is a biotechnology company developing next-generation RNA-targeted therapies to treat the world’s most challenging diseases. The ShapeTX technology platform includes RNAskip™, a proprietary suppressor tRNA technology that enables premature stop codon readthrough; RNAfixTM, a precision RNA editing technology using endogenous Adenosine Deaminase Acting on RNA (ADAR); and AAVidTM, a next-generation engineered adeno-associated virus (AAV) platform producing highly specific, tissue-tropic AAVs. The power of the ShapeTX platforms resides in redirecting the cellular machinery already present in our cells, thereby bypassing the risks of immunogenicity and DNA damage seen with other contemporary editing technologies.
At ShapeTX, we are a dynamic team of professionals who are dedicated and passionate about making cures a reality. Through diversity of thought, scientific knowledge, professional rigor and focus we are merging cutting-edge science with extensive drug development expertise to unlock cures to many debilitating diseases. Shape Therapeutics is headquartered in Seattle, Washington with a satellite site in Cambridge, Massachusetts.
ShapeTx is looking for a highly motivated individual to join the Pipeline Research team as an Associate Scientist, Pipeline Research. In this role, the successful candidate will design and execute in vitro cell-based assays to evaluate ShapeTX’s novel RNAfixTM and RNAskipTM technology platforms. The ideal candidate will have broad neurobiology experience, a collaborative spirit, and a desire to work in a fast-paced startup environment.
Roles and Responsibilities
- Collaboratively plan and execute experiments to support lead candidate selection
- Participate in multiple neurologic pipeline programs to model and quantify disease-specific pathologies in vitro as well as develop assays to measure genes/proteins of interest
- Use CRISPR/Cas9 to generate disease relevant cell lines
- Generate and utilize reporter based and functional screening tools to select lead candidates
- Conduct experiments to optimize viral vector design
- Screen for lead candidate efficacy in disease-specific neuronal cell lines, primary neural cells, and/or iPSC-derived neural cell types
- Analyze data and clearly communicate results
- Contribute to in vitro pharmacology study design and support
- Prepare written reports to support IND applications
- Maintain a detailed and up-to-date electronic laboratory notebook
- BS or MS in neurobiology, cell biology, or a related discipline with 6+ years of experience in an industry laboratory setting.
- Demonstrated scientific rigor through peer-reviewed publications or documented contributions to drug discovery project teams
- Ability to work both independently and collaboratively in a team-science environment
- Ability to think outside the box and tackle challenges with a problem-solving, can-do attitude
Skills and Experience:
- Extensive cell culture experience maintaining and differentiating neuronal cell lines, primary cells, and/or iPSC lines into neural cell types
- Experience with molecular biology techniques (DNA/RNA purification, CRISPR/Cas9, Sanger sequencing, qPCR, ddPCR)
- Experience with protein analysis techniques (ELISA, Western blotting, Flow cytometry)
- Ability to multitask and support multiple projects simultaneously
- Takes initiative with demonstrated ability to troubleshoot and think analytically
- A collaborative, team player, and good lab citizen
- Exquisite attention to detail and organization
- Effective and proactive communication